Critical Illness Clinical Trial
Official title:
Safe Limits in Saturation (SLIM-study)
A study consisting of a prospective and retrospective cohort in the ICU, ER and pulmonary
department in a university hospital in Amsterdam and a teaching hospital in Alkmaar, the
Netherlands.
The relationship between the oxygen saturation measured by pulse-oximetry and the arterial
PaO2 is investigated in order to investigate which transcutaneous saturation values are safe
when administering oxygen in relation to hyperopia and hypoxia.
This study consists of two parts a prospective and a retrospective part.
1. Prospective part: Patients in the ICU, the emergency room and the pulmonary function
department of the VU university medical centre will be included. Arterial blood gas
analysis is a tool often used to determine PaO2 in regular care. When an arterial blood
gas analysis is performed for regular patient care, the corresponding SpO2 is measured.
Information such as blood pressure, heart rate, amount of administered fluids and
shock-related-parameters are obtained from the patient files. For the ICU patients
capillary refill, acra temperature and the mottling scores are examined. The peripheral
flow index and temperature index is measured. When more arterial blood gas samples are
drawn over time in one patient, multiple datasets can be included per patient, as long
as the samples are drawn two hours apart.
2. Retrospective part: Patients with a (suspected) pulmonary disease who underwent
pulmonary function tests with arterial bloodgas sampling in the VU medical center and
Medical Centre Alkmaar in the last 25 years. The PaO2 and corresponding SpO2 will be
obtained from the test and parameters such as blood pressure, heart rate and
administered oxygen will be retrieved from the databases with these test results.
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