Mathematical Coupling of Data in Transpulmonary Thermodilution

Status Not yet recruiting

Clinical Trial Summary

The purpose of this study is to investigate whether cardiac output (CO) and global end diastolic volume (GEDV) determined from the same thermodilution curve by EV1000 are mathematically coupled during the infusion of fluid or inotropic agents in critically ill patients.

Clinical Trial Description

Some fundamental questions remain unanswered about the mathematical analysis of the thermodilution curve and the physiological significance of the Global End Diastolic Volume ( GEDV ) .

The mathematical derivation of the Global End Diastolic Volume (GEDV) is intimately linked with the Cardiac Output (CO), because EV1000, to calculate the GEDV, uses a formula in which the CO is the term "flow " for both the calculations of Volume Thermal Intra Thoracic (ITTV) and Lung Thermal volume (PTV) .

The clinical validation of GEDV as an index of preload has been substantially based on measuring changes in GEDV and CO in response to the Fluid Challenge only in patients "volume responsive".

In this scenario, GEDV and CO may show a close correlation only on the basis of their mathematical derivation. ;

Study Design

Observational Model: Case Control, Time Perspective: Prospective

Related Conditions & MeSH terms

Critical Illness

Clinical Trial Details

NCT number	NCT02239705
Study type	Observational
Source	University of Foggia
Contact	Alberto Sciusco, Doctor
Phone	0039 329 0408320
Email	albertsciusc@gmail.com
Status	Not yet recruiting
Phase	N/A
Start date	September 2014
Completion date	December 2014

View Details

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