Critical Illness Clinical Trial
Official title:
Influence of Skeletal Muscle Paralysis on Metabolism in Hypothermic Patients After Cardiac Arrest
The purpose of this study is to evaluate the impact of muscle relaxing drugs on the energy rate during hypothermia after cardiac arrest.
Mild hypothermia improves neurological outcome after cardiac arrest. Neuromuscular blockers
are in use, together with analgesia and sedation, during the cooling process in many centers
to prevent shivering. However, neuromuscular blockers are accused to be associated with
various side effects causing serious harm and/or leading to prolonged ICU stay. Furthermore,
the use of neuromuscular blockers may mask epileptic activity. Therefore, the advantages and
disadvantages of neuromuscular blockers during therapeutic hypothermia need to be
re-evaluated.
Aim of this study is to investigate if continuous application of neuromuscular blockers is
necessary to prevent shivering and thereby avoiding an increase in energy expenditure in
patients during therapeutic hypothermia and rewarming after cardiac arrest (initial 72h).
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