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NCT01361581 Clinical Trial

Metabolic Aspects of Citrate Anticoagulation in Renal Replacement Therapy

Critical Illness Clinical Trial

— Citrate  

Official title:
Metabolic Aspects of Citrate Anticoagulation in Renal Replacement Therapy

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT01361581
Other study ID # NS/10014-4
Secondary ID
Status Recruiting
Phase N/A
First received May 25, 2011
Last updated May 26, 2011
Start date January 2008

Study information
Verified date May 2011
Source Charles University, Czech Republic
Contact n/a
Is FDA regulated No
Health authority Czech Republic: Ethics Committee
Study type Observational

Clinical Trial Summary

Citrate anticoagulation is associated with metabolic side effects which are linked to a portion of citrate reaching systemic circulation. Data on significance of systemic gain of citrate and its relationship to method configuration are missing. Patient might also receive certain dose of lactate as a buffer and a dose of glucose if acid-citrate-dextrose solution is used. The authors test variable methods of indirect estimate of systemic dose of citrate which would allow to quantify the metabolic input without mostly unavailable measurements of citrate levels.

Recruitment information / eligibility
Status Recruiting
Enrollment 120
Est. completion date
Est. primary completion date
Accepts healthy volunteers No
Gender Both
Age group 16 Years and older
Eligibility Inclusion Criteria:

- Acute renal failure on continuous renal replacement therapy for more than 24 hours (CVVH or CVVHDF).

Exclusion Criteria:

- Absence of consent.

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

Locations
Country Name City State
Czech Republic Dept of Anaesthesia and Intensive Care, General University Hospital, 1st Medical Faculty, Charles University Prague 2

Sponsors (2)
Lead Sponsor Collaborator
Charles University, Czech Republic Ministry of Health, Czech Republic

Country where clinical trial is conducted

Czech Republic, 

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