Critical Illness Clinical Trial
Official title:
A Prospective, Before and After Study of the Impact of Lower Chloride Intravenous Fluid Management on Patients' Acid-base Status, Renal Profile,Length of Stay and Mortality.
The purpose of this study is to determine whether intravenous fluid management using lower chloride solutions (Hartmann's solutions and Plasmalyte®) will result in better outcome when compared to management using high chloride solutions (0.9% saline and Gelofusine®).
This is a prospective, controlled, before-and-after study. The baseline pre-intervention
period will include collection of data while doctors and nurses are unaware that such
collection is taking place. During this time, high chloride fluids (saline, Gelofusine, 4%
albumin) will continue to be used according to standard practice with an estimated 30,000
liters of saline as well as 2,000 bottles of Gelofusine® being consumed.
Following a wash out period of education and preparation, there will be a complete shift to
a working environment where use of saline, Gelofusine and any other fluids with a high
chloride level (>110 mmol/L)will be restricted and substituted with fluids of lower chloride
concentration similar to blood; either Hartmann's solution or Plasmalyte® or 20% albumin.
The study will compare a 6 month control period (before) and a six month intervention period
(after).
;
Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Treatment
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