Critical Illness Clinical Trial
Official title:
Advantages and Disadvantages of Long Term Sedation in ICU Patients
The purpose of the study is to determine whether sedation of the critical ill patient prolongs the time receiving mechanical ventilation.
The golden standard is to sedate critical ill patients receiving mechanical ventilation with
daily wake up trials. This is shown to reduce the time receiving mechanical ventilation
compared to no wake up trials.
We would like to study whether no sedation but only analgesics administered as bolus doses,
reduce the time receiving mechanical ventilation. The study is planned as a randomised
prospective study, not blinded. The control group is patients receiving sedation with daily
wake up trials. The intervention group is not sedated, but receives bolus doses of
analgesics (morphine). The endpoint is the time spend receiving mechanical ventilation,
lengths of stay on the intensive care unit, and total lengths of stay on the hospital.
We also examine the frequency of ventilator associated pneumonia and CT scans of cerebrum.
Also we would like to examine the long term psychological effects of sedation, we plan to
send some of the patients to a post traumatic stress screening. The effect on the next of
kin we plan to study with a questionnaire. As a last thing we would like to study the
workload on the nurses.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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