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Delayed Antibiotic Therapy in Non-severe Ventilator Acquired Pneumonia (VAP) — DELAVAP  

Critical Care Clinical Trial

Official title:
Aggressive Versus Restrictive Initiation of Antimicrobial Treatment in Critically Ill Patients With Suspected Ventilator Acquired Pneumonia Without Severity : a Before and After Observational Study

Clinical Trial Summary

This retro-prospective monocentric observational study compare the impact of the implementation of a restrictive (delayed) versus aggressive (immediate) antibiotic strategy for Ventilator Acquired Pneumonia suspicion without severity symptoms.

Clinical Trial Description

Ventilator acquired pneumonia (VAP) is the leading cause of nosocomial infection in intensive care patients, and has been associated with increased antibiotic consumption, increased morbidity and mortality. VAP diagnosis is difficult due to subjective or non-specific criteria. Delaying antibiotic treatment for VAP suspicion without severity symptoms raises question since the probability of VAP diagnosis, as well as the risk of delaying treatment, is very uncertain. It may nonetheless limit the environmental impact of antibiotic use which is a public health concern. We compared antibiotic sparing and patient outcome, before and after the implementation of a restrictive (delayed) antibiotic strategy versus an aggressive (immediate) antibiotic strategy in VAP suspicion without severity symptoms. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05205525
Study type Observational
Source Nantes University Hospital
Contact
Status Completed
Phase
Start date January 6, 2022
Completion date January 28, 2023
View Details
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