Pressure Support During Chest Wall Compression

Critical Care Clinical Trial

Official title:

Increasing Pressure Support During Chest Wall Compression is Useful During Respiratory Therapy?

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01155648
• Other study ID #: 07-504
• Status: Completed
• Phase: N/A
• First received: June 23, 2010
• Last updated: July 1, 2010
• Start date: May 2008
• Est. completion date: May 2010

Study information

• Verified date: June 2010
• Source: Hospital de Clinicas de Porto Alegre
• Contact: n/a
• Is FDA regulated: No
• Health authority: Brazil: National Committee of Ethics in Research
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to compare two physiotherapy techniques: chest wall compression versus chest wall compression plus increase of 10 cmH2O in inspiratory pressure.

Description:

1. After being placed in the supine position in bed, with head angle elevation at 30°, patients were randomized to:group 1 (G1): chest wall compression for ten minutes in chest or group 2 (G2): chest wall compression plus increase of 10 cmH2O in IP in PSV for ten minutes in chest.

2. Clinical variables and APACHE II were registered.

3. Parameters analyzed at the beginning (1) and at the end (2) of the protocol were:

variation of peak pressure (ΔPp=Pp2-Pp1),variation of tidal volume (ΔVT =VT2-VT1), variation of dynamic compliance (ΔCdyn= Cdyn2-Cdyn1).

4. The amount of variation of mucus secretion aspirated (ΔSa= Sa2-Sa1) at the end was also measured

Recruitment information / eligibility

• Status: Completed
• Enrollment: 66
• Est. completion date: May 2010
• Est. primary completion date: June 2009
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Patients on mechanical ventilation over 48 hours

• With ventilatory drive

• Hemodynamically stable MAP> 60 mmHg

• With treatment of respiratory therapy

Exclusion Criteria:

• Contra indication of increased positive inspiratory pressure

• Peak pressure in the upper airway > 40 cmH2O

• Osteoporosis diagnosis

• Deny to participate in the study

Study Design

Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Open Label

Related Conditions & MeSH terms

• Critical Care
• Respiration, Artificial

Intervention

Device:
• Chest wall compression plus increase of 10 cmH2O in inspiratory pressure during Pressure Support Ventilation for ten minutes in chest.

• Chest wall compression for ten minutes in chest

Locations

Country	Name	City	State
Brazil	Federal University of Rio Grande do Sul, Hospital de Clínicas de Porto Alegre	Porto Alegre	Rio Grande do Sul

Sponsors (1)

Lead Sponsor	Collaborator
Hospital de Clinicas de Porto Alegre

Country where clinical trial is conducted

Brazil, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Variation of mucus secretion aspirated.		Two years	Yes
Secondary	Hemodynamic and pulmonary parameters.	The hemodynamic and pulmonary parameters were collected: Hart rate (HH), respiratory rate (f), mean arterial pressure (MAP) and peripheral arterial saturation of oxygen (SpO2); peak inspiratory pressure (Ppeak),and Tidal volume (VT) measured in the ventilator, dynamic compliance (Cdyn calculated through the formula VT/ Ppeak - PEEP)	Two years	Yes