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The Relationship of Developing Metabolic Acidosis With Antiepleptic Drugs in Craniotomy Operations

Metabolic Acidosis Clinical Trial

Official title:
The Relationship of Developing Metabolic Acidosis With Antiepleptic Drugs in Craniotomy Operations; Does Topiramat or Zonisamide Cause Metabolic Acidosis?

Clinical Trial Summary

The relationship of developing metabolic acidosis with antiepleptic drugs in craniotomy operations

Clinical Trial Description

Metabolic acidosis is a life-threatening complication in the perioperative, intraoperative and postoperative period. It can cause decreased cardiac output, electrolyte imbalance, surgical bleeding and neurological complications, even coma and death in surgical patients. Topiramate and zonisamide are sulfonamide derivative compounds used in the treatment of epilepsy. It has been shown in studies that both drugs have a strong inhibition of carbonic anhydrase enzyme. Recent case reports suggest that both drugs may cause metabolic acidosis by lowering serum bicarbonate levels in some patients. Aim in this study is to determine the relationship between preoperative, intraoperative and postoperative metabolic acidosis and to emphasize the importance of anesthesia management in patients who have undergone craniotomy and use antiepileptic drugs. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05940935
Study type Observational
Source Trakya University
Contact
Status Completed
Phase
Start date May 22, 2023
Completion date August 15, 2023
View Details
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