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Craniofacial Microsomia clinical trials

View clinical trials related to Craniofacial Microsomia.

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NCT ID: NCT04351893 Completed - Microtia Clinical Trials

Craniofacial Microsomia: Accelerating Understanding of the Significance and Etiology

CAUSE
Start date: February 23, 2018
Phase:
Study type: Observational

The CAUSE study is a multicenter study, with domestic (n=4) and international (n=6) study sites. Children and young adults (ages 0-18) who have microtia and/or craniofacial microsomia and their parents are invited to participate. Children and parents are asked to provide a DNA sample (blood or saliva) and are asked to upload a few photos of their face. Parents are asked a short interview. Participants are able to participate from home or at one of four domestic sites.

NCT ID: NCT03806361 Completed - Clinical trials for Craniofacial Microsomia

Fat Grafts With Adipose-derived Regenerative Cells for Soft Tissue Reconstruction in Children

Start date: January 10, 2019
Phase: N/A
Study type: Interventional

Although first reports of the clinical use of adipose-derived regenerative cells (ADRC) suggest that this approach may be feasible and effective for soft tissue augmentation, there is a lack of randomized, controlled clinical trials in the literature. Hence, this study aimed to investigate whether a novel protocol for isolation of ADRC and their use in combination with fat tissue improve the long-term retention of the grafts in paediatric patients with craniofacial microsomia.

NCT ID: NCT02224677 Completed - Microtia Clinical Trials

Craniofacial Microsomia: Longitudinal Outcomes in Children Pre-Kindergarten (CLOCK)

CLOCK
Start date: November 2013
Phase:
Study type: Observational

This study is a multi-center, longitudinal cohort study of 125 infants with craniofacial microsomia (CFM) and 100 infants without craniofacial anomalies. Participants will undergo a series of evaluations between 0-3 years of age to comprehensively evaluate the developmental status of infants and toddlers with CFM. This research design will also explore specific pathways by which CFM may lead to certain outcomes. Specifically, the study explores (1) the longitudinal relations between facial asymmetry and emotion-related facial movements and socialization; and (2) associations among ear malformations, hearing and speech deficits and cognitive outcomes. Results of this research will ultimately lead to future investigations that assess new interventions and corresponding changes in current standards of care for children with CFM.

NCT ID: NCT01674439 Completed - Clinical trials for Craniofacial Microsomia

Clinical Trial of Fat Grafts Supplemented With Adipose-derived Regenerative Cells

Start date: January 2010
Phase: Phase 2
Study type: Interventional

Although first reports of the clinical use of adipose-derived regenerative cells (ADRC) suggest that this approach may be feasible and effective for soft tissue augmentation, there is a lack of randomized, controlled clinical trials in the literature. Hence, this study aimed to investigate whether a novel protocol for isolation of ADRC and their use in combination with fat tissue improve the long-term retention of the grafts in patients with craniofacial microsomia.