Cranial Nerve Diseases Clinical Trial
Official title:
Does Light and Noise Isolation Change the Melatonin Levels and Inflammatory Response After Cranial Surgery in an Intensive Care Unit
Melatonin is secreted from the epiphyseal gland with a circadian rhythm and is known to be
anti-inflammatory.
In this study, it is planned to investigate the effect of sleep disruptions on melatonin
levels and inflammation parameters in intensive care patients underwent transcranial surgery
Patients with Glasgow coma scale (GKS) >14, American Society of Anesthesiologist (ASA) I-III,
intensive care patients underwent transcranial surgery will be included
Patients will be randomly allocated by a computer generated random numbers list into two
groups.
Patients with sleep disruptions (Group I) (exposed to ambient light and noise) and Patients
without sleep disruptions (Group II) (eyes closed with patch and ear plugged; between
24:00-06:00)
Melatonin levels will be measured by urine 6-sulfatoxymelatonin (a-MT6) levels, which is a
product of melatonin degradation at 07:00 am preoperative and postoperative day 1 and day 3.
Plasma Interleukin-1 (IL-1), Interleukin- 6 (IL-6),C-reactive protein (CRP) levels will be
measured at 07:00 am preoperative and postoperative day 1and day 3.
;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Withdrawn |
NCT01932255 -
CSF Leak Following Microvascular Decompression: the Benefit of Routine Postoperative Lumbar Tap
|
N/A |