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Cowhage clinical trials

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NCT ID: NCT06340438 Not yet recruiting - Histamine Clinical Trials

Investigate the Relationship Between Catastrophizing and the Perception of Itch Intensity in Healthy Individuals

Start date: April 27, 2024
Phase: N/A
Study type: Interventional

This project aims to investigate the relationship between different dimensions of catastrophizing (rumination, magnification, and helplessness) as well as some specific personality traits related to catastrophizing tendencies like anxiety sensitivity and fear sensitivity in the modulation of itch and pain intensities in an experimental setting.

NCT ID: NCT06328543 Not yet recruiting - Histamine Clinical Trials

Itch Sensation Induced by Multiple Applications of Pruritogens (Temporal Summation)

Start date: July 1, 2024
Phase: N/A
Study type: Interventional

In This experiment, the investigators would like to design a new itch model based on the temporal summation of pruritic stimuli. The hypothesis behind this study (temporal summation) is that two overlapped applications of pruritogens will result in a higher itch sensation compared with a single application.

NCT ID: NCT06328530 Recruiting - Histamine Clinical Trials

Itch Sensation Induced by Simultaneous Application of Pruritogens (Spatial Summation)

Start date: April 1, 2024
Phase: N/A
Study type: Interventional

In This experiment, the investigators would like to design a new itch model based on the spatial summation of pruritic stimuli. The hypothesis behind this study (spatial summation) is that two simultaneous applications of pruritogens will result in higher itch sensation compared with a single application of pruritogen.

NCT ID: NCT06154824 Recruiting - Histamine Clinical Trials

Repetitive Applications of Pruritogens and Effects of a Cutaneous-induced Pain Stimulation on Nonhistaminergic Itch Perception

Start date: December 15, 2023
Phase: N/A
Study type: Interventional

In This experiment, the investigators would like to test following hypotheses: repetitive cutaneous administration of pruritogens will lead to a more robust and longer lasting itch sensation compared with a single application. The aim of this project is to investigate a new itch model based on repetitive administration of three different pruritogens: histamine (histaminergic itch), cowhage, and BAM 8-22 (non-histaminergic itch).

NCT ID: NCT06081998 Recruiting - Sleep Deprivation Clinical Trials

Investigation of the Effects of Sleep Deprivation on Itch and Pain Sensitivity

Start date: November 1, 2023
Phase: N/A
Study type: Interventional

In This experiment, the investigators would like to test following hypotheses regarding the influence of sleep deprivation on itch: - To investigate similarity and differences between itch and pain by comparing the effect of sleep deprivation in them. - To evaluate the inflammatory state induced by sleep fragmentation via the analysis of C-reactive protein (CRP) levels from blood samples. - To correlate the anxiety and depression scores (evaluated through questionnaires) with itch and pain sensitivity and evaluate how they are affected by sleep. In This experiment, the investigators would like to test following hypotheses regarding the influence of sleep fragmentation on itch: - To investigate similarity and differences between itch and pain by comparing the effect of sleep deprivation in them. - To evaluate the inflammatory state induced by sleep fragmentation via the analysis of C-reactive protein (CRP) levels from blood samples. - To correlate the anxiety and depression scores (evaluated through questionnaires) with itch and pain sensitivity and evaluate how they are affected by sleep deprivation.

NCT ID: NCT06081946 Recruiting - Sleep Fragmentation Clinical Trials

Investigation of the Effects of Sleep Fragmentation on Itch and Pain Sensitivity

Start date: December 15, 2023
Phase: N/A
Study type: Interventional

In This experiment, the investigators would like to test following hypotheses regarding the influence of sleep fragmentation on itch: - To investigate similarity and differences between itch and pain by comparing the effect of sleep deprivation in them. - To evaluate the inflammatory state induced by sleep fragmentation via the analysis of C-reactive protein (CRP) levels from blood samples. - To correlate the anxiety and depression scores (evaluated through questionnaires) with itch and pain sensitivity and evaluate how they are affected by sleep fragmentation.

NCT ID: NCT04672382 Completed - Morphine Clinical Trials

Evaluation of Peripheral Itch Mechanisms Following Injection of Morphine

Start date: July 1, 2021
Phase: N/A
Study type: Interventional

The aim of this study is to the effect of opioid (morphine) intradermal application on histaminergic and non-histaminergic itch. In particular, we would like to demonstrate that also peripheral administration of morphine may affect mast cell release of histamine.

NCT ID: NCT03576053 Completed - Itch Clinical Trials

A Mechanistic Evaluation of the Interactions Between Thermoceptive and Pruriceptive Sensory Processing

Start date: July 1, 2018
Phase: N/A
Study type: Interventional

The purpose of this human experimental study is to evaluate the pattern of itch intensity over time in response to strong, short-term heat stimulation in two different models of histamine and cowhage-induced itch. Moreover, the purpose is to evaluate the effect of mild pre-heating of the skin in human experimental models of histamine, cowhage and serotonin. Finally, we want to investigate the effect of short-term intense heat stimulation on previously anesthetized skin.