Cow Milk Allergy Clinical Trial
Official title:
Diagnosis of Cow's Milk Protein Allergy Among Infants and Children in Assuit University
The study will assess the diagnosis of Cow's milk protein allergy (CMPA) among infant and children in Assiut University Children Hospital using skin prick test and specific serum IgE
Food allergy is a reproducible specific immune response to the exposure to a given food.
Cow's milk protein allergy (CMPA) is a clinically abnormal reaction to cow's milk protein
(CMP) via immune mechanisms triggered by milk protein (Boyce etal., 2010) .
According to the European Academy for Allergy and Clinical Immunology (EAACI) and the World
Allergy Organization (WAO), a hypersensitivity reaction to cow's milk involving the immune
system can be called as CMPA.There is difference between CMPA and non-allergic cow's milk
intolerance (e.glactose intolerance) which occurs as a result of lactase deficiency without
involvement of the immune system (Venter etal ., 2013) .
CMPA is categorized into immunoglobulin IgE mediated, non-IgE mediated, or mixed
CMPA(Sichereretal ., 2001) .
1.9% to 4.9% prevalence of CMPA among children with a peak in prevalence (2-3%) in the first
year of life and prevalence of <1% in children aged ≥6 years(Koletzkoetal ., 2012) .
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