Arthropathy of Knee Clinical Trial
Official title:
Neuroendocrine Changes Associated With Magnesium Sulfate Administration in Surgical Patients
Total knee arthroplasty is a procedure that relieves pain in patients with severe symptomatic osteoarthritis, but it can be associated with postoperative pain, which hinders recovery. In the previous study, we reported evidence of increased pain in patients undergoing staged total knee arthroplasty, in whom the second operated knee had greater sensitivity (tertiary hyperalgesia) as a result of the surgical injury to the first operated knee. Magnesium sulfate is an effective analgesic adjuvant for postoperative pain. Its analgesic property seems to be associated with the regulation of calcium influx into the cells, or antagonism of N-methyl-D-aspartate receptors in the central nervous system. Additionally, magnesium is known to have an anti-inflammatory effect. Inflammatory state may accompany with pain via peripheral or central sensitization. Recently, we reported that magnesium sulfate effectively attenuates not only postoperative pain but also increased pain intensity without serious adverse effects in the bilateral staged total knee arthroplasty. However, the exact mechanism regarding these effects of magnesium sulfate remains unclear. In the present study, we will investigate the analgesic mechanism of magnesium sulfate via analysis of endocrine neurosteroid levels in patients undergoing bilateral staged total knee arthroplasty.
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Terminated |
NCT03940651 -
Cardiac and Renal Biomarkers in Arthroplasty Surgery
|
Phase 4 | |
| Completed |
NCT05593341 -
Opioid Education in Total Knee Arthroplasty
|
N/A | |
| Not yet recruiting |
NCT05290818 -
Total Versus Robotic Assisted Unicompartmental Knee Replacement
|
N/A | |
| Withdrawn |
NCT04099355 -
Investigating the Effect of Dronabinol on Post-surgical Pain
|
Early Phase 1 | |
| Recruiting |
NCT04924205 -
A Comparison Of Primary TKA Rehabilitation Using A Smart Orthotic Versus Outpatient Physical Therapy
|
N/A | |
| Completed |
NCT05399043 -
Experience of Use and Biopsychosocial Effects of Robotic and Virtual Reality Devices in Neuromotor Rehabilitation
|
N/A | |
| Terminated |
NCT03185117 -
Opioid Consumption After Hospital Discharge in Orthopedic Surgery
|
||
| Completed |
NCT04118023 -
7T MRI to Evaluate Cartilage Defects in the Knee
|
||
| Terminated |
NCT03260699 -
Economic and Functional Impact of Peri-Operative Bracing for Primary Total Knee Arthroplasty (TKA)
|
N/A | |
| Recruiting |
NCT03283878 -
Antibiotic Prophylaxis in Patients Undergoing Elective TKA- Multi-center Trial
|
Phase 4 | |
| Completed |
NCT03133481 -
Adductor Canal Block Versus Femoral Nerve Block for Total Knee Arthroplasty
|
Phase 3 | |
| Active, not recruiting |
NCT04684160 -
Comparison of Joint Awareness Between Fixed-bearing and Mobile-bearing Total Knee Arthroplasty Using Titanium-nitride Coated Posterior-stabilized Prostheses
|
N/A | |
| Completed |
NCT03282201 -
A Survey on Blood Transfusions in Major Artrhoplasty Operations
|
||
| Recruiting |
NCT06259032 -
Comparative Effect of Mechanical and Functional Alignment in Bilateral Total Knee Arthroplasty on Ankle Alignment
|
N/A | |
| Completed |
NCT02928562 -
The Impaction of Exercise Training on Bone Mineral Density in Patients After Total Knee Arthroplasty
|
N/A | |
| Completed |
NCT04481711 -
Total Knee Arthroplasty and Clinical Findings
|
N/A | |
| Recruiting |
NCT01135160 -
Evaluation of Weight Bearing After Total Hip and Knee Replacement
|
||
| Completed |
NCT03921034 -
IPACK Nerve Block for Total Knee Arthroplasty
|
Phase 4 | |
| Active, not recruiting |
NCT05248815 -
Muscle Strength and Total Knee Replacement
|
||
| Not yet recruiting |
NCT06024161 -
Weight Change and the Risk of Chronic Pain Following Hip and Knee Arthroplasties
|