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sFlt1: a Biomarker of Organ Dysfunction in Critically-ill Patients With COVID-19? — COVIDsFlt1  

CORONAVIRUS INFECTIONS Clinical Trial

Official title:
sFlt1: a Biomarker of Organ Dysfunction in Critically-ill Patients With COVID-19?

Clinical Trial Summary

Short description of the protocol intended for the lay public. Include a brief statement of the study hypothesis (Limit : 5000 characters) The management of critically-ill patients with organ failure due to COVID-19 represents a major healthcare burden. While endothelial inflammation has been reported in these patients, the pathophysiological mechanisms remain incompletely elucidated.

Clinical Trial Description

Extended description of the protocol, including more technical information (as compared to the Brief Summary) if desired. Do not include the entire protocol; do not duplicate information recorded in other data elements, such as eligibility criteria or outcome measures. (Limit : 32 000 characters) The soluble fms-like tyrosine kinase 1 (SFlt1) is the soluble form of VEGF-A receptor 1 (VEGFR1). By linking VEGF-A with a high affinity, sFlt1 blocks the VEGF-A / VEFR1 axis and impairs endothelial homeostasis. Its production increases during inflammation. We hypothesize that sFlt1 is upregulated and correlates with endothelial dysfunction and outcomes in critically-ill patients with COVID-19. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04394195
Study type Observational
Source CHU de Reims
Contact
Status Completed
Phase
Start date April 3, 2020
Completion date September 1, 2020
View Details
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