Coronavirus Infection Clinical Trial
Official title:
Assessing the Effects of Coronavirus Disease (COVID-19) on Multiple Organ Systems and Impact on Quality of Life, Functional Capacity and Mental Health
The C-MORE study is prospective observational holistic longitudinal study which will characterise the prevalence of multi-organ injury among COVID-19 survivors post hospital discharge and assess its effects on quality of life, exercise tolerance and mental health.
Since the outbreak of Coronavirus disease (COVID-19), hundreds of thousands of lives have
been lost and millions significantly affected. Although primarily a respiratory viral
illness, emerging data suggests that multiorgan involvement is common in those with
moderate-severe infections. Whether or not persistent multiorgan damage will be seen in
COVID-19 survivors is unknown.
C-MORE is an observational study that aims to investigate the long-term effects of COVID-19
on the lungs, heart, brain, liver and kidneys using advanced state-of-the art magnetic
resonance imaging (MRI) technology. The study will assess 616 patients with
laboratory-confirmed COVID-19 from leading UK centres and undertake multi-organ magnetic
resonance imaging at 3, 6, and 12 months following the onset of COVID-19 symptoms. In
addition, assessments of breathing, exercise capacity, cognition and mental health will be
carried out.
The study will describe the prevalence of persistent multi-organ injury in COVID-19 patients
and assess how this relates to comorbid conditions, severity of acute respiratory illness,
immunological response, genetic factors, quality of life and mental health.
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