Therapeutic Effect of Sildenafil in Patients With Coronary Vasospasm

Coronary Vasospasm Clinical Trial

Official title:

Application of Sildenafil in Patients With Documented Coronary Vasospasm to Explore the Pathophysiology of Coronary Vasospasm and the Therapeutic Effect of Sildenafil in Patients Suffering From Coronary Vasospasm

Clinical Trial Details — Status: Withdrawn

Administrative data

• NCT number: NCT00454714
• Other study ID #: RBK091
• Status: Withdrawn
• Phase: Phase 3
• First received: March 29, 2007
• Last updated: April 10, 2017
• Start date: March 1, 2007
• Est. completion date: December 31, 2009

Study information

• Verified date: April 2017
• Source: Robert Bosch Gesellschaft für Medizinische Forschung mbH
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This will be a prospective, phase IIIb, double-blind and randomized trial testing the effect of single dose sildenafil application in patients with coronary vasospasm compared to placebo application.

The target variable to be tested is the degree of coronary vasoconstriction in response to intracoronary ACh application (in addition to clinical chest pain) which will be imaged by coronary angiography and measured using quantitative coronary angiography software.

Main objective: Has sildenafil the potency to inhibit the induction of coronary vasospasm by intracoronary ACh-application in patients with proven coronary artery spasm?

Secondary objective: Which degree of coronary vasospasm inhibition can be achieved with sildenafil?

Description:

Coronary artery spasm is an abrupt severe vasoconstrictor response which may occur spontaneously in normal and diseased coronary arteries. It may result in myocardial ischemia and may be provoked by various stimuli such as acetylcholine (ACh). Coronary vasospasm is involved in the pathogenesis of Prinzmetal's angina, acute myocardial infarction or sudden cardiac death due to ventricular arrythmias and chest pain symptoms associated with viral myocarditis.

The precise cellular and molecular mechanisms of coronary vasospasm have not yet been elucidated. The most often suggested but competing explanations for this disease are coronary endothelial dysfunction secondary to impaired nitric oxide production versus coronary smooth muscle cell hyperreactivity with or without additional endothelial dysfunction. As the precise cellular mechanism is currently unknown a large group of people can currently not be treated appropriately despite the use of nitrates and calcium antagonists.

Sildenafil is a phosphodiesterase(PDE)-5 inhibitor approved for the treatment of both erectile dysfunction and pulmonary hypertension. PDE-5 has been shown to be also present and play an important vasomotor role in the coronary vessel wall. Application of the inhibitor sildenafil has been shown to increase the resting coronary artery diameter. Furthermore, atherosclerotic coronary artery segments which vasoconstrict following intracoronary ACh-application vasodilate following the application of sildenafil when ACh-testing is repeated. Other studies are also suggesting an improved endothelial function after sildenafil application for both the coronary and the peripheral vasculature.

Taken together, sildenafil is expected to have a positive effect on coronary vasomotility. Whether sildenafil can totally prevent the occurrence of coronary vasospasm or at least decrease the severity of vasospasm has not been studied so far. Thus, the aim of this study is to analyse the possible anti-spastic effects of sildenafil in patients suffering from coronary vasospasm.

Recruitment information / eligibility

• Status: Withdrawn
• Enrollment: 0
• Est. completion date: December 31, 2009
• Est. primary completion date: December 31, 2009
• Accepts healthy volunteers: No
• Gender: All
• Age group: 50 Years and older

Eligibility

Inclusion Criteria:

• age = 50y

• Framingham risk score < 10%

• no contraindication to sildenafil application

• clinical history of atypical angina pectoris

• exclusion of significant coronary artery disease (stenosis = 50%) by coronary angiography

• documented coronary spasm by ACh-testing in at least one coronary artery segment

• written informed consent

Exclusion Criteria:

• existing contraindication to sildenafil application

• significant coronary artery disease (= 50%)

• valvular, inflammatory, dilative or other cardiomyopathies

• congestive heart failure (left ventricular ejection fraction < 60%) of any reason

• need for therapeutic treatment with nitrates or intake of any nitrates in the last 24h before coronary angiography

• participation in another clinical trial at the moment or in the last 30 days

• hypotonic blood pressure (<90/50mmHg)

• hepatic insufficiency (> Child-Pugh-classification A)

• renal insufficiency with a GFR < 60ml/min- pregnancy or lactation

• not able to consent

Related Conditions & MeSH terms

• Coronary Vasospasm

Intervention

Drug:
• single dose Sildenafil
Application of a single dose Sildenafil
• Single dose placebo
Application of a single dose placebo

Locations

Country	Name	City	State
Germany	Robert-Bosch-Krankenhaus	Stuttgart

Sponsors (1)

Lead Sponsor	Collaborator
Udo Sechtem

Country where clinical trial is conducted

Germany, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Incidence of coronary vasospasm in spite of medical treatment		After inclusion of last patient