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Clinical Trial Summary

The evidence demonstrating the importance of coronary microcirculation in the management of patients with coronary artery disease is growing. For example, in recent years, a number of studies have demonstrated that the presence of coronary microvascular disease (CMVD) contributes to increased cardiovascular morbidity and mortality independent of the extent and severity of coronary epicardial disease. The index of microcirculatory resistance (IMR) is an invasive index proposed for the diagnosis of CMVD. The ability of IMR to motivate therapeutic changes in order to subsequently reduce symptoms and improves the quality of life of our patients with stable coronary artery disease (CAD) was recently demonstrated. The prognostic value of IMR has also been shown in stable CAD with PCI. Thus, after optimal epicardial revascularization, IMR could represent a tool for personalized medicine adapted to the presence of severe CMVD. The aim of the study is to to demonstrate a positive effect of personalized medicine on angina in patients with epicardial revascularization by PCI and with significant CMVD assessed by IMR.

Clinical Trial Description


Study Design

Related Conditions & MeSH terms

NCT number NCT05178914
Study type Interventional
Source University Hospital, Grenoble
Contact Gilles Barone Rochette
Phone +33476765172
Email [email protected]
Status Not yet recruiting
Phase N/A
Start date March 2022
Completion date March 2025

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