Coronary Artery Ectasia Clinical Trial
Official title:
Ischemia and Inflammatory Markers Among Patients With Coronary Artery Ectasia
study the ischemic burden in patients with CAE, and its relation to inflammatory markers. - To assess the ischemic response during exercise ECG among patients with different variants of CAE. - To assess inflammatory biomarkers among patient with different variants of CAE - To assess the relation between the ischemic response and inflammatory markers.
Status | Not yet recruiting |
Enrollment | 90 |
Est. completion date | January 2026 |
Est. primary completion date | January 2025 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 70 Years |
Eligibility | Inclusion Criteria: - Subjects with suspected CAD who are undergoing elective coronary angiography. Exclusion Criteria: Patients with a history of cardiomyopathy or myocardial infarction (MI). Patients with recent acute coronary syndrome Patients with severe renal impairment Post CABG patients Patients with physical incapacity |
Country | Name | City | State |
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n/a |
Lead Sponsor | Collaborator |
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Assiut University |
Aboeata AS, Sontineni SP, Alla VM, Esterbrooks DJ. Coronary artery ectasia: current concepts and interventions. Front Biosci (Elite Ed). 2012 Jan 1;4(1):300-10. doi: 10.2741/377. — View Citation
Antoniadis AP, Chatzizisis YS, Giannoglou GD. Pathogenetic mechanisms of coronary ectasia. Int J Cardiol. 2008 Nov 28;130(3):335-43. doi: 10.1016/j.ijcard.2008.05.071. Epub 2008 Aug 9. — View Citation
Dereli S, Cerik IB, Kaya A, Bektas O. Assessment of the Relationship Between C-Reactive Protein-to-Albumin Ratio and the Presence and Severity of Isolated Coronary Artery Ectasia. Angiology. 2020 Oct;71(9):840-846. doi: 10.1177/0003319720930983. Epub 2020 Jun 10. — View Citation
Devabhaktuni S, Mercedes A, Diep J, Ahsan C. Coronary Artery Ectasia-A Review of Current Literature. Curr Cardiol Rev. 2016;12(4):318-323. doi: 10.2174/1573403x12666160504100159. — View Citation
Eitan A, Roguin A. Coronary artery ectasia: new insights into pathophysiology, diagnosis, and treatment. Coron Artery Dis. 2016 Aug;27(5):420-8. doi: 10.1097/MCA.0000000000000379. — View Citation
Huang QJ, Liu J, Chen MH, Li JJ. Relation of diabetes to coronary artery ectasia: A meta-analysis study. Anadolu Kardiyol Derg. 2014 Jun;14(4):322-7. doi: 10.5152/akd.2014.5327. Epub 2014 May 2. — View Citation
Mavrogeni S. Coronary artery ectasia: from diagnosis to treatment. Hellenic J Cardiol. 2010 Mar-Apr;51(2):158-63. No abstract available. — View Citation
Shao Q, Chen K, Rha SW, Lim HE, Li G, Liu T. Usefulness of Neutrophil/Lymphocyte Ratio as a Predictor of Atrial Fibrillation: A Meta-analysis. Arch Med Res. 2015 Apr;46(3):199-206. doi: 10.1016/j.arcmed.2015.03.011. Epub 2015 May 14. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Ischemia and Inflammatory markers among patients with coronary artery ectasia . | Incidence of exercise induced ischemic changes on stress ECG: ST-T changes and chest pain reported by patient. | 2 years | |
Secondary | Ischemia and Inflammatory markers among patients with coronary artery ectasia . | Assays of inflammatory markers measured at a fixed time interval among patients as: NLR, RDW, hs-CRP, IL6. | 2 years |
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