The Effects of Dexmedetomidine on cTnI and GP-BB in Patients Undergoing OPCABG

Coronary Artery Bypass, Off-Pump Clinical Trial

Official title:

The Effects of Dexmedetomidine on Cardiac Troponin I and Glycogen Phosphorylase Isoenzyme BB in Patients Undergoing Off-pump Coronary Artery Bypass Grafting

Clinical Trial Details — Status: Active, not recruiting

Administrative data

• NCT number: NCT03163693
• Other study ID #: 2015-NW-028
• Status: Active, not recruiting
• Phase: N/A
• First received: May 15, 2017
• Last updated: May 20, 2017
• Start date: February 2016
• Est. completion date: May 2017

Study information

• Verified date: May 2017
• Source: General Hospital of Ningxia Medical University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to observe the impact of dexmedetomidine on Cardiac Troponin I and Glycogen Phosphorylase Isoenzyme BB in patients undergoing off-pump coronary artery bypass Grafting.

Description:

Dexmedetomidine is a highly selective α2-adrenoceptor agonist used as a sedative or adjuvant anesthetic drug in clinical settings.From clinical observation, dexmedetomidine has been revealed to reduce the incidence of cardiovascular adverse events in patients with heart diseases during non‑cardiac surgeries.Therefore, the aim of this sudy is to observe the impact of dexmedetomidine on Cardiac Troponin I and Glycogen Phosphorylase Isoenzyme BB in patients during cardiac surgeries.

Recruitment information / eligibility

• Status: Active, not recruiting
• Enrollment: 40
• Est. completion date: May 2017
• Est. primary completion date: May 2017
• Accepts healthy volunteers: No
• Gender: All
• Age group: 40 Years to 70 Years

Eligibility

Inclusion Criteria:

• Patients undergoing off - pump coronary artery bypass grafting

• ASA physical status III-IV

• Aged 40-70 years

• NYHA physical status II-III

Exclusion Criteria:

• Bradycardia

• Atrioventricular block

• Echocardiography suggested:LVEF <40%, LVED>65mm

• Allergic to the drugs

Related Conditions & MeSH terms

• Coronary Artery Bypass, Off-Pump

Intervention

Drug:
• dexmedetomidine
receive dexmedetomidine 0.5 µg/kg

Other:
• normal saline
receive equal volume of normal saline

Locations

Country	Name	City	State
China	General Hospital of Ningxia Medical University	Yinchuan	Ningxia

Sponsors (1)

Lead Sponsor	Collaborator
General Hospital of Ningxia Medical University

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Change of cardiac troponin I at preoperative, postoperative,and 24 hours after surgery.	Blood samples were sampled at preoperative, postoperative,and 24 hours after surgery for the cTnI,which were analyzed by using enzyme linked immunosorbent assay (ELISA).	At preoperative, postoperative,and 24 hours after surgery.
Primary	Change of Glycogen Phosphorylase Isoenzyme BB at preoperative, postoperative,and 24 hours after surgery.	Blood samples were sampled at preoperative, postoperative,and 24 hours after surgery for the GP-BB,which were analyzed by using enzyme linked immunosorbent assay (ELISA).	At preoperative, postoperative,and 24 hours after surgery.