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Clinical Trial Summary

This IMPROVE trial plans to enroll 648 patients who are diagnosed with coronary artery disease and are going to take off-pump CABG in five centers in China, to access whether RIC can and improve short-term prognosis.


Clinical Trial Description

Remote ischemic conditioning (RIC) is the process of repeated ischemia and reperfusion in the peripheral vessels, which is proved in reducing IRI in vital organs. However, the effect of RIC in patients undergoing off-pump CABG is still unclear. This IMPROVE trial plans to enroll 648 patients who are diagnosed with coronary artery disease and are going to take off-pump CABG in five centers in China, to access whether RIC can and improve short-term prognosis. Patients will be randomly assigned into RIC group and control group. The primary outcome is the occurrence of the major adverse cardiovascular and cerebrovascular events (MACCE) within the 3-month follow-up. The MACCE is defined as all-cause of death, myocardial infarction, stroke and coronary revascularization surgery. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT06141525
Study type Interventional
Source First Affiliated Hospital Xi'an Jiaotong University
Contact Yang Yan
Phone +86.29.85323869
Email yangyan3@xjtu.edu.cn
Status Not yet recruiting
Phase N/A
Start date December 1, 2024
Completion date March 31, 2029

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