Dexmedetomidine Clinical Trial
Official title:
The Comparison of Serum Potassium Concentration, Antiarrhythmic Effect, and Myocardial Protective Effect Between Dexmedetomidine and Remifentanil Infusion in Patients Undergoing Coronary Artery Bypass Surgery
We are trying to investigate whether intraoperative dexmedetomidine infusion could decrease the incidence of intraoperative hypokalemia and arrhythmia, and myocardial injury in patients undergoing off-pump coronary artery bypass graft, and trying compare these effects with those of remifentanil infusion.
Alpha2-adrenergic agonist, dexmedetomidine, is recently used for sedation, analgesia or
adjuvant to general anesthesia. Postsynaptic activation of alpha2 adrenoceptors in the
central nervous system (CNS) inhibits sympathetic activity and thus can decrease blood
pressure and heart rate. The blockade of sympathetic activity decrease the neuroendocrine
stress response and may decrease the incidence of hypokalemia. The hypokalemia can increase
the incidence of arrythmia, especially in cardiac patients. We postulated that
dexmedetomidine could decrease the neuroendocrine stress response, thus decrease arrhythmia
during cardiac surgery. Furthermore, dexmedetomidine have been reported to have
cardioprotective effect with previous animal studies.
Therefore, the aim of the present study is to investigate whether the intraoperative
dexmedetomidine infusion can reduce the incidence of hypokalemia and arrythmia, and
myocardial injury in subjects undergoing off-pump coronary artery bypass graft. We are also
trying to compare these effects with those of remifentanil infusion.
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Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Subject)
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