Computer Cognitive Training for Post-acute COVID-19 Syndrome — PACS-Cog  

Cognitive Dysfunction Clinical Trial

Official title: An Open-label Trial of Computer-delivered Cognitive Training in Persons With Post-acute COVID-19 Syndrome

Status Completed

Clinical Trial Summary

This study will assess the acceptability, feasibility, and impact of game-based computer-delivered cognitive training on cognitive function in persons with cognitive symptoms that persist after recovery from acute coronavirus-19 (COVID) infection.

Clinical Trial Description

Over the course of the past several years, it has become apparent that a number of individuals have residual symptoms after COVID-19 infection after they have recovered from the acute phase of the illness (Al-Aly, Xie, & Bowe, 2021; Davis et al., 2021; Greenhalgh, Knight, A'Court, Buxton, & Husain, 2020; Hewitt et al., 2021). The constellation of symptoms experienced by these individuals has been termed "post-acute COVID syndrome" or PACS (Nalbandian et al., 2021). A key part of helping affected individuals is supporting their efforts at self-management of these symptoms (National Institute for Health and Care Excellence, 2020; Wade, 2020). Although a diverse number of physical and psychological symptoms have been seen as sequelae of COVID (Davis et al., 2021), among the most troubling for patients have been difficulties in attention, concentration, working memory, and long-term memory, commonly referred to as "brain fog" (Graham et al., 2021; Hampshire et al., 2021; Hewitt et al., 2021). In the proposed study, we will complete a pilot study of game-based cognitive training in persons with symptoms of long COVID using a protocol that was useful and acceptable to participants in a previous study (Ownby & Kim, 2021). We will explore participants' views on the cognitive training intervention, its effects on their perceived cognitive functioning, and assess the intervention's impact on participants' processing speed. We will also explore their preferences for type of cognitive training activity and the impact of information about memory functioning. ;

Related Conditions & MeSH terms

• Cognitive Dysfunction
• Corona Virus Infection
• Coronavirus Infections

• NCT number: NCT05338749
• Study type: Interventional
• Source: Nova Southeastern University
• Status: Completed
• Phase: N/A
• Start date: April 26, 2022
• Completion date: November 30, 2023