Corneal Transplantation Clinical Trial
Official title:
Prospective, Randomized Trial of Basiliximab (Simulect) in the Prophylaxis of High-Risk Keratoplasty Patients
Most high risk keratoplasties are currently performed under systemic immunosuppression.
Immunosuppressants are currently either Cyclosporine A or mycophenolate mofetile,
administered for around 6 months. Due to potentially severe adverse effects, new
immunosuppressive exerting less side effects would be desirable. Basiliximab is a
monoclonal, chimeric antibody, targeted specifically against the Interleukin-2-Rezeptor from
activated T-cells. This agent is known to specifically inhibit T-cell proliferation upon
intravenous application only twice following transplantation. Basiliximab has already been
demonstrated effective in kidney transplantation.
This investigation is a prospective, randomized clinical trial on orthotopic, high-risk
penetrating keratoplasty. Basiliximab is evaluated against systemic Cyclosporine A. Primary
endpoint is graft rejection. Secondary endpoint is clear graft survival.
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Prevention
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT01206127 -
DSAEK- Postoperative Positioning and Transplant Dislocation
|
N/A | |
| Terminated |
NCT00764582 -
Ocular Penetration of 1.5% Levofloxacin and 0.5% Moxifloxacin During Corneal Transplant Surgery
|
Phase 4 | |
| Recruiting |
NCT05870566 -
Pretreatment to Promote Graft Survival After Subsequent High-risk Corneal Transplantation [CrossCornealVision]
|
N/A | |
| Recruiting |
NCT02084745 -
Timing of Glaucoma Drainage Device With Boston Keratoprosthesis
|
N/A | |
| Unknown status |
NCT00834782 -
Comparison of DCT, ORA and GAT in Eyes After Penetrating Keratoplasty
|
Phase 4 | |
| Withdrawn |
NCT00345020 -
Deep Lamellar Endothelial Keratoplasty: Small Incision Technique
|
||
| Completed |
NCT00000137 -
Collaborative Corneal Transplantation Studies (CCTS)
|
Phase 3 | |
| Recruiting |
NCT04339907 -
Inflammatory Mediators of Glaucoma After Corneal Transplantation (AH-Tears)
|
N/A | |
| Active, not recruiting |
NCT00874835 -
Corneal Endothelium Delivery Instrument
|
Phase 2 | |
| Completed |
NCT00570648 -
A Prospective Study of the Effect of Topical Sodium Hyaluronate Immediately Post-PKP on Time to Reepithelialization
|
N/A | |
| Enrolling by invitation |
NCT03461978 -
Ultrahigh-resolution Optical Coherence Tomography Imaging of the Anterior Eye Segment Structures
|
N/A | |
| Not yet recruiting |
NCT05210478 -
Intraoperative Optical Coherence Tomography for Ophthalmic Surgical Guidance - Cornea
|
||
| Completed |
NCT01694914 -
Comparative Study of Two Corneal Graft Storage Media: New Animal Compound Free Medium Versus Reference Medium
|
Phase 3 | |
| Completed |
NCT03381794 -
The German Keratoplasty Registry of the German Ophthalmological Society (DOG)
|
N/A | |
| Recruiting |
NCT03105466 -
Prospective Study of Deep Anterior Lamellar Keratoplasty Using Acellular Porcine Cornea
|
N/A | |
| Recruiting |
NCT01018888 -
Safety and Efficacy Study of Artificial Cornea
|
Phase 4 | |
| Recruiting |
NCT04490902 -
Clinical Study on the Treatment of Mixed Component Cornea for High Risk Keratoplasty
|
N/A | |
| Recruiting |
NCT04337944 -
Endoscopic Assisted Anterior Hyaloid Peeling in Boston Type 1 Keratoprosthesis (KPro-HP-Endo)
|
N/A | |
| Completed |
NCT01547975 -
Retrospective Analysis of Surgical Outcomes After Corneal Transplantation
|
N/A | |
| Terminated |
NCT00447642 -
Study to Assess LX201 for Prevention of Corneal Allograft Rejection or Graft Failure in Subjects Who Have Experienced One or More Rejection Episodes Following Penetrating Keratoplasty
|
Phase 3 |