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Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT00512876
Other study ID # WRAMC WU# 07-23022
Secondary ID
Status Completed
Phase N/A
First received August 6, 2007
Last updated July 3, 2013
Start date August 2007
Est. completion date January 2011

Study information

Verified date July 2013
Source Walter Reed Army Medical Center
Contact n/a
Is FDA regulated No
Health authority United States: Federal Government
Study type Interventional

Clinical Trial Summary

Purpose: To determine the efficacy and safety of one commonly used VEGF inhibitor, bevacizumab (Avastin, Genentech), as a topical agent for the treatment of corneal neovascularization.


Recruitment information / eligibility

Status Completed
Enrollment 24
Est. completion date January 2011
Est. primary completion date January 2011
Accepts healthy volunteers Accepts Healthy Volunteers
Gender Both
Age group 18 Years to 74 Years
Eligibility Inclusion Criteria:

- male or female, at least 18 years of age

- clinically stable corneal neovascularization

- superficial or deep corneal neovascularization that extends farther than 2mm from the limbus

- ability to understand and provide informed consent to participate in this study and willingness to follow study instructions and likely to complete all required visits.

Clinical stability - all of the following criterial should be excluded before a corneal neovascularization can be regarded as clinically stable:

- current or recent (<3 months) episode of corneal and ocular surface infection (bacterial, viral, fungal, or acanthamoebal)

- recent (<3 months) ocular surgery, including cataract surgery, and/or laser of any type in the study eye

- recent (<6 months) full thickness or lamellar keratoplasty

- recent (<6 months) ocular surface reconstruction, limbal auto or allograft stem cell transplantation, or amniotic membrane transplantation

- current or recent (<3 months) use of contact lens or plan to use contact lens (excluding bandage contact lens)

- current or recent (<3 months) persistent corneal epithelial defect (of at leat 14 days duration) measuring more than 1mm2

Exclusion Criteria:

- current or recent (<1 month) systemic corticosteroid therapy or periocular corticosteroid injections to the study eye

- current or recent (<3 months) intravitreal durg injection to the study eye.

- recent (<1 month) change in dose and frequency of topical steroids and/or non-steroidal anti-inflammatory agents

- uncontrolled hypertension defined as systolic blood pressure >150 mmHg or diastolic blood pressure of >90 mmHg

- history of a thromboembolic event, including myocardial infarction or cerebral vascular accident

- patients age 75 or older

- history of renal abnormalities

- recent (<3 months) or planned surgery

- history of coagulation abnormalities, including end stage liver disease or current anticoagulation medication other than aspirin (warfarin, heparin, enoxaparin or similar anticoagulant agent)

- all female patients of childbearing potential will be excluded. A female is considered to be of childbearing potential unless she is postmenopausal and without menses for 12 months or without a uterus and/or both ovaries.

- any condition (including language barrier) that precludes patient's ability to comply with study requirements including completion of study.

- any condition that precludes the patient's ability or an assisting family member's ability to apply the medication drops or to sustain five minutes of pressure on the lacrimal ducts after drop application.

- concurrent enrollment in another clinical investigation medicinal product or device study is prohibited.

Study Design

Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment


Intervention

Drug:
Bevacizumab (Avastin)
Bevacizumab 10mg/mL 1 drop BID x 3 weeks

Locations

Country Name City State
United States Walter Reed Army Medical Center Washington District of Columbia

Sponsors (2)

Lead Sponsor Collaborator
Walter Reed Army Medical Center Massachusetts Eye and Ear Infirmary

Country where clinical trial is conducted

United States, 

Outcome

Type Measure Description Time frame Safety issue
Primary Adverse Events (Ocular and Systemic) 24 weeks Yes
Secondary Size and Extent of Corneal Neovascularization computerized image analysis of the corneal photographs were used to measure the change in size and extent of corneal neovascularization from baseline. 24 weeks No
See also
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Recruiting NCT04787471 - Corneal Crosslinking for Treatment of Corneal Neovascularization Phase 2/Phase 3
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Active, not recruiting NCT00992849 - Bevacizumab for the Treatment of Corneal Neovascularization Phase 2
Withdrawn NCT00515684 - Corneal Thinning During Topical Bevacizumab Therapy N/A
Terminated NCT02797704 - Subconjunctival Aflibercept (EYLEA®) for the Treatment of Corneal Neovascularization Phase 1/Phase 2
Terminated NCT01868360 - Using Aflibercept Injection to Treat Blood Vessel Growth Over the Cornea Phase 1
Withdrawn NCT02042027 - Subconjunctival IVIg (Gamunex-C) Injection for Corneal Neovascularization and Inflammatory Conditions Phase 1
Recruiting NCT04215393 - An Exploratory Clinical Trial Evaluating the Tolerability and Efficacy of KH906 in Patients With Corneal Neovascularization Phase 1
Completed NCT00797303 - The Effect of Bevacizumab on Corneal Neovascularization Phase 4
Recruiting NCT05659940 - Correlation Between a Novel Subset of Neutrophil and Corneal Neovascularization.
Completed NCT00559936 - Topical Avastin for Treatment of Corneal Neovascularization Phase 1
Completed NCT01072357 - Safety and Efficacy of Bevacizumab in High-Risk Corneal Transplant Survival Phase 1/Phase 2
Recruiting NCT04620109 - Clinical Evaluation of Safety and Tolerability of KDR2-2 Eye Drops in Healthy Volunteers With Pharmacokinetic Assessment Phase 1
Recruiting NCT05011916 - The Safety and Efficacy of KDR2-2 Suspension Eye Drops in the Treatment of Corneal Neovascularization Phase 1/Phase 2
Completed NCT01996826 - A Multi-Center Study of the Safety and Efficacy of Bevacizumab in High-Risk Corneal Transplant Survival Phase 1/Phase 2
Terminated NCT00915590 - Topical IL-1-Ra for Treatment of Corneal Neovascularization Phase 1/Phase 2