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NCT00471406 Clinical Trial

Photodynamic Therapy With Verteporfin for Corneal Neovascularization

Corneal Neovascularization Clinical Trial

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT00471406
Other study ID # CPDT-0001
Secondary ID
Status Completed
Phase N/A
First received May 8, 2007
Last updated October 16, 2008

Study information
Verified date October 2008
Source Chonnam National University Hospital
Contact n/a
Is FDA regulated No
Health authority Korea: Food and Drug Administration
Study type Interventional

Clinical Trial Summary

Purpose: To investigate the efficacy of photodynamic therapy with verteporfin for the treatment of patients with corneal neovascularization.

Design: Prospective, non-comparative case series. Participants: Eighteen eyes of 18 patients with stable corneal neovascularization who were refractory to conventional treatment.

Methods: The patients were treated with photodynamic therapy with verteporfin (6 mg/m2). Five patients were treated following penetrating keratoplasty, and 2 patients were treated before penetrating keratoplasty. Best corrected visual acuity and anterior segment photography were performed before and after treatment. The length of cumulative blood vessels and area of corneal neovascularization were measured.

Main outcome measures: Vascular occlusion, best corrected visual acuity, cumulative blood vessel length, and corneal neovascularization area.

Recruitment information / eligibility
Status Completed
Enrollment 0
Est. completion date
Est. primary completion date
Accepts healthy volunteers
Gender Both
Age group 35 Years to 70 Years
Eligibility Inclusion Criteria:

- Patients with clinically stable corneal neovascularization who were not improved after treatment with 1% prednisolone acetate eyedrops instilled 4 times a day for at least 1 month

Exclusion Criteria:

- Individuals who had active keratitis with vessel proliferation, uncontrolled inflammation, active hepatitis or clinically significant liver disease, or porphyria or other porphyrin sensitivity

Study Design

Allocation: Non-Randomized, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

Intervention

Procedure:
• Photodynamic Therapy with Verteporfin

Locations
Country Name City State
n/a

Sponsors (1)
Lead Sponsor Collaborator
Chonnam National University Hospital
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