Corneal Epithelium Exfoliation Clinical Trial
Official title:
0.3% Sodium Hyaluronate Eye Drop to Prevent Recurrent Corneal Epithelium Exfoliation After Corneal Abrasions: a Pilot Study
Corneal abrasion (TCA) is the most common ophthalmic emergency disease, accounting for about
10% of the American ophthalmic emergency, accounting for 22% of the ophthalmic emergency in
Zhongshan Ophthalmic Center. Clinical emergency treatment of TCA is relatively simple and
effective, corneal epithelial damage can be recovered within 48 hours. However, about 25%
TCA would be developed to the recurrence of exfoliation. Once the recurrence of TCA, the
treatment would be more difficult and even cause blindness. Therefore, it is of great
practical significance to prevent the recurrence of TCA. However, there is no effective
methods to prevent recurrence of TCA.
0.3% sodium hyaluronate eye drops can effectively supplement the shortage of tear and
promote repair of corneal epithelium. On this basis, the investigators hypotheses that 0.3%
sodium hyaluronate eye drops can prevent the recurrence of TCA. So, investigators intend to
test effectiveness of 0.3% sodium hyaluronate drops to prevent the recurrence of TCA by a
prospective, single center, randomized, controlled pilot study. In this study, 60 patients
with TCA were randomly divided into control group and sodium hyaluronate treatment group and
observed one year.
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Prevention