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Corneal Dystrophies, Hereditary clinical trials

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NCT ID: NCT06202651 Recruiting - Clinical trials for Granular Dystrophy, Corneal

Neodymium-doped Yttrium Aluminum Garnet (Nd:YAG) Laser Treatment for Granular Corneal Dystrophy

Start date: January 26, 2022
Phase: N/A
Study type: Interventional

Granular Corneal Dystrophy is a rare hereditary disease characterized by the development of deposits within the cornea, which may in turn affect the quality of vision. Still today, all existing treatment options are based on surgical intervention and there is no minimally-invasive treatment available for the disease. The goal of this clinical trial is to test the effectiveness and safety of Neodymium-doped yttrium aluminum garnet (Nd:YAG) laser as a minimally-invasive treatment for people suffering from Granular Corneal Dystrophy. The main question it aims to answer is if Nd:YAG laser is able to disintegrate the characteristic corneal depositions in a safe manner without causing significant adverse effects. If found suitable to be part of the study, participants will first undergo a series of imaging studies to measure and characterize the corneal deposits. After completion, the participants will undergo the Nd:YAG laser treatment under local anesthesia by a corneal specialist, targeting deposits not involving the visual axis. Following the treatment, participants might need to take antibiotic eye drops for a duration of approximately one week. The participants will be required to attend two follow-up visits: one week after the treatment and 3 months after the treatment. In each one of the follow-up visits, an eye examination will be performed and the same series of imaging studies that was performed prior to the Nd:YAG laser treatment will be repeated.

NCT ID: NCT06101017 Recruiting - Corneal Disease Clinical Trials

Developing a Nationwide Registry to Track Longitudinal Clinical Outcomes of Corneal Surgery and Disease

Start date: October 12, 2023
Phase:
Study type: Observational

The goal is to develop a nationwide registry to track longitudinal clinical outcomes of and store imaging data related to numerous corneal conditions. There are two main objectives including the establishment of the first nationwide corneal transplant registry in the United States to include information related to the donor tissue, recipient, surgical procedure, and long-term clinical outcomes. Ultimately, this prospective data collection will allow us to determine prognostic factors for successful corneal transplantation and create an algorithm to guide clinical practice based on real world outcomes. The second objective is to collect and create a database of historical, de-identified optical coherence topography (OCT) and corneal topography images to ultimately develop artificial intelligence (AI) based diagnostic and prognostic algorithms for corneal disease and surgery.

NCT ID: NCT05832684 Recruiting - Clinical trials for Bietti's Crystalline Dystrophy

Safety and Efficacy of ZVS101e in Patients With Bietti 's Crystalline Dystrophy

Start date: February 20, 2023
Phase: Phase 1/Phase 2
Study type: Interventional

The purpose of this study was to evaluate the safety and efficacy of ZVS101e administered by subretinal injection in subjects with Bietti's crystalline dystrophy (BCD) and to select the optimal effective dose.

NCT ID: NCT05826353 Recruiting - Clinical trials for Fuchs Endothelial Corneal Dystrophy

A Study to Investigate the Safety and Efficacy of K-321 Eye Drops After Simultaneous Cataract Surgery and Descemetorhexis in Participants With Fuchs Endothelial Corneal Dystrophy (FECD)

Start date: May 11, 2023
Phase: Phase 3
Study type: Interventional

A study to assess the safety and efficacy of K-321 in participants with FECD after simultaneous cataract surgery and descemetorhexis.

NCT ID: NCT05795699 Recruiting - Clinical trials for Fuchs Endothelial Corneal Dystrophy

A Study to Evaluate the Safety and Efficacy of K-321 Eye Drops After Descemetorhexis in Participants With Fuchs Endothelial Corneal Dystrophy (FECD)

Start date: March 30, 2023
Phase: Phase 3
Study type: Interventional

A study to assess the safety and efficacy of K-321 in participants with FECD after descemetorhexis.

NCT ID: NCT05714904 Recruiting - Clinical trials for Bietti's Crystalline Dystrophy

Safety and Tolerability of ZVS101e in Patients With Bietti 's Crystalline Dystrophy

Start date: September 23, 2022
Phase: Early Phase 1
Study type: Interventional

The purpose of the study is to evaluate the safety and tolerability of an adeno-associated virus vector expressing CYP4V2 in patients with Bietti's crystalline dystrophy (BCD).

NCT ID: NCT05399069 Recruiting - Clinical trials for Bietti Crystalline Dystrophy

Safety and Tolerability of VGR-R01 in Patients With Bietti Crystalline Dystrophy

Start date: September 15, 2022
Phase: Early Phase 1
Study type: Interventional

An Open-Label, Non-Randomized, Uncontrolled, Single-dose Pilot Study of VGR-R01 in Patients with Bietti Crystalline Dystrophy.

NCT ID: NCT04722107 Recruiting - Clinical trials for Bietti's Crystalline Dystrophy

Safety Study of rAAV2/8-hCYP4V2 in Patients With Bietti's Crystalline Dystrophy (BCD)

Start date: April 21, 2021
Phase: Early Phase 1
Study type: Interventional

Primary Objectives: To evaluate the safety of rAAV2/8-hCYP4V2 gene replacement therapy drug administered as a single subretinal injection in patients with Bietti's Crystalline Dystrophy (BCD). Secondary Objectives: To preliminarily explore the clinical effectiveness of rAAV2/8-hCYP4V2 gene replacement therapy drugs.

NCT ID: NCT04440280 Recruiting - Clinical trials for Fuchs Endothelial Corneal Dystrophy

Targeting Reactive Oxygen Species Production as a Novel Therapeutic in Fuch's Endothelial Corneal Dystrophy

Start date: September 16, 2020
Phase: Phase 2
Study type: Interventional

This protocol will investigate whether topical application of N-acetyl cysteine (NAC) eye drops decreases oxidative stress and confers cytoprotection in patients with FECD.

NCT ID: NCT04387331 Recruiting - Clinical trials for Pseudophakic Bullous Keratopathy

The Postoperative Head Position as a Predictor of the Surgical Outcome After DMEK

Start date: May 11, 2020
Phase:
Study type: Observational

This study aims to investigate the influence of postoperative head position on clinical outcomes after DMEK via a wearable sensor.