Corneal Diseases Clinical Trial
Official title:
A Pilot Study Using the Dynamic Light Scattering Device (DLS) Combined With Keratoscopy on the Cornea in Vivo
This pilot study will examine the usefulness of a new instrument called the Dynamic Light
Scattering (DLS) device for documenting and monitoring changes in the cornea, the front part
of the eye where contact lenses are placed. The DLS device uses a low-intensity laser
similar to that used in supermarket checkouts to measure the cloudiness of the cornea. The
results of this study may lead to further investigations using DLS to discover the cause of
corneal clouding and to develop treatments to prevent it.
Healthy volunteers and patients with corneal clouding or opacification 18 years of age and
older may be eligible for this study.
Participants will have a standard eye examination, including a check of visual acuity and
eye pressure. The retina will also be examined and photographs of the cornea may be taken.
For the DLS test, the subject sits in front of the device and looks at a yellow-green target
while the cloudiness of the cornea is measured. Subjects will be tested four times. The
entire procedure takes less than 30 minutes.
Corneal disease and injuries are the leading cause of visits to eye care clinics in the US today. These diseases are also some of the most painful eye disorders. Two important areas for research on the cornea are 1) to explore and understand the molecular basis of corneal transparency and 2) to analyze the molecular nature of corneal inflammation and wound healing. We have developed a new clinical device to understand molecular changes that occur in the lens, called Dynamic Light Scattering (DLS) device. Studies have shown its potential in the detection of the earliest changes occurring in the cataract, and have also shown good test retest reproducibility of the system. We now would like to apply this technique to study changes that occur in corneal opacification. In this pilot project, we would like to study the normal cornea in young and older persons (volunteers) as well as cloudy, opaque corneas. This will allow us to determine if useful data can be obtained, and if so, lead to further studies in various corneal disorders caused by trauma, infections, and dystrophies, as well as those caused by systemic or inherited disorders. ;
N/A
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT02291731 -
Autologous Serum Eye Drops With Contact Lenses for Corneal Epithelial Defects
|
N/A | |
| Completed |
NCT00810472 -
Functional Antigen Matching in Corneal Transplantation
|
N/A | |
| Completed |
NCT00029185 -
Study of Dehydrex in Patients With Corneal Erosion
|
N/A | |
| Enrolling by invitation |
NCT03436576 -
Efficacy of Two Concentrations of Autologous Serum for the Treatment of Severe Dry Eye
|
Phase 3 | |
| Completed |
NCT02344732 -
Effect of Systemic Oxygen on Corneal Epithelial Wound Healing in Diabetic Patients Undergoing Pars Plana Vitrectomy
|
N/A | |
| Recruiting |
NCT06451172 -
Novel Antisense Oligonucleotide Eye Drops for Treating Antibiotic-Resistant Bacterial Keratitis
|
Early Phase 1 | |
| Not yet recruiting |
NCT05833737 -
Corneal Findings in Patients Treated With Belantamab Mafodotin
|
||
| Completed |
NCT04421300 -
A Randomized Study of Smile Exercise for Dry Eye
|
N/A | |
| Completed |
NCT00396188 -
Screening Aid to Identify Corneas That May Have Pathologies or Other Conditions
|
Phase 1 | |
| Terminated |
NCT03029104 -
Collagen Cross-Linking With Ultraviolet-A in Asymmetric Corneas
|
Phase 2 | |
| Completed |
NCT02348242 -
Ocular Surface Disorders in Patients in Intensive Care Units, a Comparative Study of Three Preventive Approaches
|
N/A | |
| Recruiting |
NCT04164407 -
Keratoconus, Corneal Diseases and Transplant Registry
|
||
| Withdrawn |
NCT05052554 -
Study With QR-504a to Evaluate Safety, Tolerability & Corneal Endothelium Molecular Biomarker(s) in Subjects With FECD3
|
Phase 1 | |
| Terminated |
NCT00447187 -
Study to Assess the Efficacy and Safety of LX201 for Prevention of Corneal Allograft Rejection Episodes and Graft Failure in Subjects at Increased Immunological Risk
|
Phase 3 | |
| Completed |
NCT00491439 -
Using in Vivo Confocal Microscope to Evaluate the Corneal Wound Healing After Various Ocular Surgeries
|
N/A |