Corneal Disease Clinical Trial
Official title:
A Single Arm, Open Label, Multicenter Clinical Investigation to Evaluate the Clinical Safety and Performance of the CorNeat Keratoprosthesis, for Treatment of Corneal Blindness
A Single Arm, Pivotal, Open Label, Multicenter Clinical Investigation to Evaluate the Clinical Safety and Performance of the CorNeat Keratoprosthesis, for Treatment of Corneal Blindness
This clinical trial will assess the clinical safety and performance of the CorNeat Keratoprosthesis (KPro), a synthetic, artificial cornea for or the treatment of corneal blindness in subjects who are not candidates for traditional corneal transplant. 40 subjects who are willing to take part in the study will undergo screening examinations to verify their eligibility. The CorNeat KPro will be implanted unilaterally in eligible subjects. Follow up procedures will be performed at 1 day, 1 week, 2 weeks, 1, 2, 3, 4, 5, 6,8, 10,12,15,18,21 and 24 months post-surgery and will include clinical assessment of the implanted eye using slit-lamp biomicroscopy, intra ocular pressure measurement and ocular imaging. Additionally, subjects' visual acuity will be assessed and recorded throughout the 24 months follow up period. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT05114928 -
Correlation Between Q-value Changes and Progression of Pediatric Keratoconus.
|
||
| Recruiting |
NCT06160960 -
Influence of Pupillary Behavior During Eye Surgery on Morphological and Functional Outcome
|
||
| Completed |
NCT00357435 -
Studies in Families With Corneal Dystrophy or Other Inherited Corneal Diseases
|
||
| Completed |
NCT04484402 -
Treatment of Patients With Inflammatory-dystrophic Diseases of the Cornea Using Autologous Stem Cells
|
Phase 1/Phase 2 | |
| Not yet recruiting |
NCT05581875 -
A Study to Investigate the Safety and Clinical Activity of Belantamab Mafodotin in Combination With Daratumumab, Pomalidomide and Dexamethasone in Patients With Relapsed/ Refractory Multiple Myeloma Previously Treated With One Line Therapy Who Are Lenalidomide Refractory
|
Phase 1/Phase 2 | |
| Recruiting |
NCT06101017 -
Developing a Nationwide Registry to Track Longitudinal Clinical Outcomes of Corneal Surgery and Disease
|
||
| Withdrawn |
NCT03421548 -
Implantable Intraocular Pressure Sensor for Glaucoma Monitoring in Patients With Boston Keratoprosthesis Type 1
|
N/A | |
| Withdrawn |
NCT05700864 -
NGF Treatment for Patients With Neuropathic Corneal Pain
|
Phase 1 | |
| Enrolling by invitation |
NCT05758753 -
QST for Corneal Nerve Function
|
N/A | |
| Terminated |
NCT00001310 -
Tissue Studies of Human Eye Diseases
|
||
| Completed |
NCT02386774 -
Innovative Imaging of the Conjunctiva, Cornea, and Ocular Adnexa
|
N/A | |
| Not yet recruiting |
NCT06294015 -
Efficacy of 20% Autologous Serum Drops in the Treatment of Corneal Epitheliopathy Associated With Antihypertensive Glaucoma Drops.
|
Phase 4 | |
| Completed |
NCT00654888 -
Automated Lamellar Keratectomy in Symptomatic Patients With Bullous Keratopathy
|
N/A | |
| Recruiting |
NCT04251143 -
Dresden Corneal Disease and Treatment Study
|
||
| Withdrawn |
NCT02374723 -
Evaluation of Biosynthetic Constructs to Replace Donor Corneas
|
Phase 1 | |
| Completed |
NCT01384487 -
Nidek RS3000 Comparative Study
|
N/A | |
| Completed |
NCT00804505 -
Hybrid SA RGP Center/S-H Skirt Daily Wear 90 Day Multicenter Study
|
N/A | |
| Completed |
NCT04475900 -
Computer-aided Diagnosis of Ocular Diseases Based on Corneal Biomechanics
|
||
| Recruiting |
NCT05573802 -
A Study to Investigate Safety and Clinical Activity of Belantamab Mafodotin in Combination With Lenalidomide, Dexamethasone and Nirogacestat in Patients With Transplant Ineligible Newly Diagnosed Multiple Myeloma
|
Phase 1/Phase 2 | |
| Terminated |
NCT04485858 -
First in Human (FIH) Study to Assess Safety and Efficacy of the CorNeat KPro for the Treatment of Corneal Blindness
|
N/A |