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Clinical Trial Summary

The goal of this clinical trial is to learn if haploidentical hematopoietic cell transplantation combined with an unrelated cord blood unit (haplo-cord HCT) works to treat acute T cell lymphoblastic leukemia (T-ALL). It will also learn about the safety of the transplantation. The main questions it aims to answer are: Dose co-infusion of cord blood in haploidentical hematopoietic cell transplantation (haplo-HCT) lower the rate of relapse? What medical problems do participants have when having haplo-cord HCT? Researchers will compare haplo-cord HCT to haplo-HCT to see if haplo-cord HCT works to treat T-ALL. Participants will be infused an unrelated cord blood unit at the same day of haploidentical graft infusion.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms

  • Cord Blood
  • Haploidentical Hematopoietic Stem Cell Transplantation
  • Leukemia
  • Leukemia, Lymphoid
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma
  • Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

NCT number NCT06381817
Study type Interventional
Source The First Affiliated Hospital of Soochow University
Contact Yang XU
Phone 86+051267781850
Email xuyang1020@126.com
Status Recruiting
Phase Phase 3
Start date April 1, 2024
Completion date March 31, 2028

See also
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Recruiting NCT06423131 - Prospective Clinical Trial for Children With TCRαβ Depleted vs Traditional Haplo Identicle HSCT N/A
Recruiting NCT02014506 - Haploidentical Allogeneic Hematopoietic Stem Cell Transplantation in Children and Adolescents Phase 1/Phase 2
Recruiting NCT05166967 - Individualized Dose Study of ATG in Haploidentical Hematopoietic Stem Cell Transplantation Phase 4
Active, not recruiting NCT04778618 - Individualized Dose Study of ATG in Haploidentical Hematopoietic Stem Cell Transplantation Phase 2
Completed NCT03236220 - Effect of NAC on the Hematopoietic Reconstitution After Haploidentical Hematopoietic Stem Cell Transplantation Phase 2