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Live Vaccines and Innate Immune Training in COPD. — COPD-LIVE  

COPD Clinical Trial

Official title:
Using Live Vaccines to Induce Beneficial Innate Immune Training and Reduce Systemic Inflammation in COPD Patients.

Clinical Trial Summary

A randomized, single-blinded clinical pilot study to assess whether vaccination with live attenuated vaccines can induce trained immunity and cause beneficial changes in patients with COPD.

Clinical Trial Description

Single-blinded 1:1:1 block randomized controlled trial (with varying block sizes of 3-6), stratified by sex. A total of 60 participants will be recruited and randomly assigned with 20 in each treatment arm. Separated by three months, the participants will receive two doses of one of the following three treatments: 1. MMR vaccine (M-M-R VaxPro) 2. BCG vaccine (Danish strain 1331) 3. Saline (placebo) ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06257212
Study type Interventional
Source Chronic Obstructive Pulmonary Disease Trial Network, Denmark
Contact Josefin Eklöf, MD,Phd
Phone +4538673555
Email josefin.viktoria.ekloef@regionh.dk
Status Recruiting
Phase Phase 4
Start date February 28, 2024
Completion date September 2025
View Details
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