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Oral Citrulline Supplementation in COPD Patients With Malnutrition — CITRUS  

Malnutrition Clinical Trial

Official title:
Effects of Oral Citrulline Supplementation on Fat-free Mass in COPD Patients With Malnutrition

Clinical Trial Summary

Chronic obstructive pulmonary disease (COPD) is complicated by malnutrition in 20-70% of cases. In COPD, low fat-free mass is associated with a higher risk of morbidity and mortality. L-citrulline is a non-protein amino acid that has a direct effect on muscle protein synthesis. Oral supplementation with L-citrulline (10 g/day) in malnourished patients has shown to increase fat-free mass. The effects of L-citrulline supplementation in malnourished COPD patients are unknown. The main objective of this prospective, single-centre, randomised, double-blind, placebo-controlled study will be to determine the impact of 45 days of nutritional supplementation with L-citrulline (10 g/day) on lean body mass (fat-free mass index (in kg.m-2) measured by bioelectrical impedance analysis) in malnourished patients (BMI < 20 kg/m2 if < 70 years old or < 22 kg/m2 if ≥ 70 years old) with COPD at stages 3-4 of the GOLD classification.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06212765
Study type Interventional
Source University Hospital, Grenoble
Contact Bruno Degano, MD, PhD
Phone 0033476766400
Email bdegano@chu-grenoble.fr
Status Not yet recruiting
Phase Phase 3
Start date January 25, 2024
Completion date September 25, 2026
View Details
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