COPD Clinical Trial
— C-FINDOfficial title:
COPD Case Finding In Nottingham and District: C-FIND COPD A Pilot Study
The Targeted Lung Health Check (TLHC) is currently being rolled out in many regions of the United Kingdom and has just started in Nottingham. The same cohort of people are also at high risk for Chronic Obstructive Pulmonary Disease (COPD), a lung condition often caused by smoking and leading to breathlessness and cough. This study aims to provide pilot evidence of the role of breathing tests in those who have had a Computerised Tomography (CT) scan, in order to early diagnose COPD. Currently, at diagnosis, many patients have lost 30-40% of lung function already, which is not reversible. This study will use the Nottingham University Hospitals Trust Mobile Research Unit. The unit will follow the CT scanner route 2-3 weeks later, and people who have had a CT scan will be invited for breathing tests. Participants will also collect further information on potential treatment options for people diagnosed with COPD earlier -including smoking cessation, symptom management and general health advice (vaccinations, diet, activity and managing infections). There is also an optional blood test. The study aims are to determine the uptake and acceptability of breathing tests in patients at high risk of COPD, and if a community based approach co-locating with TLHC can increase uptake.
Status | Recruiting |
Enrollment | 600 |
Est. completion date | October 31, 2024 |
Est. primary completion date | October 31, 2024 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 40 Years and older |
Eligibility | Inclusion Criteria: - Smoking history - either compatible with TLHC (current or ex-smoker who are high risk based on lung cancer risk scores) or if self-presenting >10 pack years (current or ex) - Able to provide full informed consent. Exclusion Criteria: - People currently undergoing active investigation or treatment for cancer - Unable to provide informed consent |
Country | Name | City | State |
---|---|---|---|
United Kingdom | Nottingham University Hospitals NHS Trust | Nottingham | Nottinghamshire |
Lead Sponsor | Collaborator |
---|---|
Nottingham University Hospitals NHS Trust | University of Nottingham |
United Kingdom,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Proportion of people who take up the invite to attend for a C-FIND visit. | 0-100% | 1.5 years | |
Secondary | Proportion diagnosed with COPD | 0-100% | 1.5 years | |
Secondary | CAT COPD Quality of Life Score | Questionnaire. Wellbeing and daily life questions, scored 0-40 points, lower better | 1 day | |
Secondary | MRC breathlessness score | Questionnaire, self reported breathlessness grade 1-5, lower better | 1 day | |
Secondary | Exacerbation Frequency | 0-12/year | 1 day | |
Secondary | EQ-5D-5L - Health Status | Questionnaire. Self reported health scale 0-100. Greater better | 1 day | |
Secondary | Oximetry for oxygen saturations | 75-100% Oxygen saturation | 1 day | |
Secondary | Height | Participant height in metres - range 1.2-2.0m | 1 day | |
Secondary | Weight | participant weight in Kg - range 35-180Kg | 1 day | |
Secondary | BMI | 12-60g/m2 | 1 day | |
Secondary | Blood pressure diastolic | 40-120mmHg | 1 day | |
Secondary | Post bronchodilator Spirometry | Forced Expired Volume (FEV)% - range 10-140% predicted | 1 day | |
Secondary | FOT-R (Resistance) | cmH2O.s/l | 1 day | |
Secondary | FOT-X (reactance) | cmH2O.s/l | 1 day | |
Secondary | FOT-AX (area of reactance) | cmH2O/L | 1 day | |
Secondary | FOT-Fres (resonant Frequency) | Hz | 1 day | |
Secondary | Blood pressure -systolic | 75-230mmHg | 1 day |
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