The Effect of HFNC on Exercise Capacity Compared to VM in COPD Patients Recovering From Acute Evacerbation

COPD Clinical Trial

Official title:

The Effect of High Flow Nasal Cannula on Exercise Capacity Compared to Venturi Mask in COPD Patients Recovering From Acute Evacerbation

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT05097560
• Other study ID #: FAHGZ-20210811
• Status: Recruiting
• Phase: N/A
• Start date: August 11, 2021
• Est. completion date: August 31, 2022

Study information

• Verified date: October 2021
• Source: The First Affiliated Hospital of Guangzhou Medical University
• Contact: Shiying Fang, MD
• Phone: +8602083062882
• Email: fangshiying2019[@]126.com
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Early PR is thought to be effective in COPD patients recovering from acute exacerbation, while the effect of HFNC during exercise training in these patients remains unclear. The study may provide evidence of early PR in COPD patients recovering from acute exacerbation.

Description:

We hypothesize that HFNC may increases exercise time in COPD patients recovering from acute exacerbation compare to VM. A randomized, cross-over clinical trial in which either HFNC or VM may be used as an adjunct in 10-MST in random order, respectively, will be performed to compare the endurance time. The physiological effect of HFNC and VM during exercise will also be measured to explore the mechanism.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 10
• Est. completion date: August 31, 2022
• Est. primary completion date: May 31, 2022
• Accepts healthy volunteers: No
• Gender: All
• Age group: 40 Years to 80 Years

Eligibility

Inclusion Criteria:

• hospitalized AECOPD patients

• be ambulatory by 48h after admission for AECOPD

• requires oxygen by screening exercise test

Exclusion Criteria:

• active coronary ischemia

• respiratory diseases other than COPD

• unstable vital signs

• unstable psychological status

Related Conditions & MeSH terms

• COPD

Intervention

Device:
• high flow nasal cannula
HFNC provides humidified, heated, oxygen-enriched air at constant concentration with a flow up to 60L/min through a nasal cannula. It washouts the anatomical dead space and decreases the work of breathing.
• Venturi mask
VM is commonly used by COPD patients during exercise training.

Locations

Country	Name	City	State
China	Shiying	Guangzhou	Guangdong

Sponsors (1)

Lead Sponsor	Collaborator
The First Affiliated Hospital of Guangzhou Medical University

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Endurance time	Endurance time for 10 minute steping test	10 minute
Secondary	Respiratory pattern	Respiratory pattern is calculated by the flow and time	10 minute
Secondary	Work of breathing	Work of breathing is calculated by the transdiaphragmatic pressure	10 minute
Secondary	Neural respiratory drive	Neural respiratory drive is calculated by diaphragm electromyogram	10 minute