Chronic Obstructive Pulmonary Disease Clinical Trial
Official title:
The Microcirculatory Characteristics of the Heart and Lung Meridians: A Study of COPD Patients and Healthy Adults
Although some important progresses were made in the field of the meridian research, no breakthroughs have been achieved. Besides,there are some problems in meridian researches. The majority of the existing studies involve lots of subjective assessments for meridian phenomena. In addition, few studies have investigated the site specificity between two specific meridians.Therefore, this study is designed to detect the microcirculatory characteristics of meridian phenomena by using an objective assessment tool and investigate the site specificity for the meridian-visceral association and surface-surface association between two specific meridians.
Status | Not yet recruiting |
Enrollment | 120 |
Est. completion date | December 2021 |
Est. primary completion date | December 2020 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 20 Years to 75 Years |
Eligibility |
Inclusion Criteria: Inclusion criteria for COPD patients - Patients should meet the COPD diagnostic criteria, and the severity of COPD is in the stage of GOLD 2 or 3 based on pulmonary function testing; - COPD patients in the stable phase and present with mild symptoms; - 35 = age =75 years, male or female; - Patients have clear consciousness and could communicate with others normally; - Patients could understand the full study protocol and written informed consent is signed. Inclusion criteria for healthy volunteers - Healthy volunteers who could provide a recent medical examination report to confirm they have not any cardiovascular, respiratory, digestive, urinary, hematological, endocrine and neurological disease; - age =20 years, male or female; - Participants have clear consciousness and could communicate with others normally; - Participants could understand the full study protocol and written informed consent is signed. Exclusion Criteria: Exclusion criteria for COPD patients - Patients who fail to meet the diagnostic criteria for COPD, or COPD patients in the phase of acute exacerbation; - Patients have the following complications, such as bronchial asthma, bronchiectasis, active tuberculosis, pneumothorax, chest trauma, tumors of the lung or thorax; - Patients have concomitant conditions of heart diseases, such as chronic stable angina pectoris; - Patients have serious concomitant conditions and fail to treat them effectively, such as diseases of the digestive, urinary, respiratory, hematological, and nervous system; - Patients have mental illness, severe depression, alcohol dependence or history of drug abuse; - Pregnant or lactating patients; Patients are participating in other trials. Exclusion criteria of healthy volunteers - Participants have mental illness, severe depression, alcohol dependence or history of drug abuse; - Pregnant or lactating participants ; - Participants are participating in other trials |
Country | Name | City | State |
---|---|---|---|
China | the Third affiliated hospital of Zhejiang Chinese Medical university | Hangzhou | Zhejiang |
Lead Sponsor | Collaborator |
---|---|
Zhejiang Chinese Medical University | The Third Affiliated hospital of Zhejiang Chinese Medical University |
China,
Hsiu H, Hsu WC, Hsu CL, Huang SM, Jan MY, Wang WK, Wang YY. Spectral analysis on the microcirculatory laser Doppler signal at the acupuncture point. Conf Proc IEEE Eng Med Biol Soc. 2008;2008:1084-6. doi: 10.1109/IEMBS.2008.4649348. — View Citation
Hsiu H, Hsu WC, Huang SM, Hsu CL, Lin Wang YY. Spectral analysis of the microcirculatory laser Doppler signal at the Hoku acupuncture point. Lasers Med Sci. 2009 May;24(3):353-8. doi: 10.1007/s10103-008-0569-8. Epub 2008 May 27. — View Citation
Hsiu H, Hsu WC, Wu YF, Hsu CL, Chen CY. Differences in the skin-surface laser Doppler signals between polycystic ovary syndrome and normal subjects. Microcirculation. 2014 Feb;21(2):124-30. doi: 10.1111/micc.12095. — View Citation
Hsiu H, Huang SM, Chao PT, Jan MY, Hsu TL, Wang WK, Wang YY. Microcirculatory characteristics of acupuncture points obtained by laser Doppler flowmetry. Physiol Meas. 2007 Oct;28(10):N77-86. Epub 2007 Sep 18. — View Citation
Zheng SX, Xu JS, Pan XH, Hu XL. [Comparison of microcirculatory blood perfusion between acupoints of the stomach meridian and their bilateral control points and changes of blood flow after electroacupuncture in 21 volunteer subjects]. Zhen Ci Yan Jiu. 2012 Feb;37(1):53-8. Chinese. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Change from baseline blood flow curve | Laser doppler flowmetry is used to assess blood flow curve of relevant sites along the Heart and Lung meridians | 5-minute baseline, 15 minutes during moxibustion and 5 minutes after stopping moxibustion | |
Primary | Change from baseline blood perfusion units | Laser doppler flowmetry is used to assess blood perfusion units of relevant sites along the Heart and Lung meridians | 5-minute baseline, 15 minutes during moxibustion and 5 minutes after stopping moxibustion |
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