The Differences of Muscle Activity Between Patients With COPD and Healthy Adults

Chronic Obstructive Pulmonary Disease Clinical Trial

Official title:

Comparing Activity of Accessory Inspiratory Muscles and Upper Limb Muscles During Performing Activities of Daily Living Between Patients With Chronic Obstructive Pulmonary Disease and Healthy Adults

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT04146948
• Other study ID #: A-ER-108-273
• Status: Recruiting
• Start date: January 22, 2020
• Est. completion date: December 2021

Study information

• Verified date: March 2021
• Source: National Cheng-Kung University Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The purpose of this study attempts to investigate the differences and relationships of respiratory parameters, muscle activity, and dyspnea during ADL between patients with COPD and age-matched healthy participants.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 60
• Est. completion date: December 2021
• Est. primary completion date: December 2021
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 40 Years and older

Eligibility

Inclusion Criteria:

• 40 years or older
• With the clinical diagnosis of COPD

Exclusion Criteria:

• With the clinical diagnosis of asthma or cancer
• With cardiovascular, musculoskeletal and neurological diseases limiting physical activities in daily life
• In the unstable medical state
• MMSE under 25
• Barthel index score under 61

Related Conditions & MeSH terms

• Chronic Obstructive Pulmonary Disease
• Lung Diseases
• Lung Diseases, Obstructive
• Pulmonary Disease, Chronic Obstructive

Intervention

Other:
• no intervention
no intervention in this study

Locations

Country	Name	City	State
Taiwan	National Cheng-Kung University	Tainan

Sponsors (1)

Lead Sponsor	Collaborator
National Cheng-Kung University Hospital

Country where clinical trial is conducted

Taiwan, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Cardiopulmonary exercise testing device	The machine analyze the breath of participants including oxygen consumption and minute ventilation volume. Oxygen consumption is reported in mL/min and minute ventilation volume is reported in L/min.	baseline
Primary	Surface electromyography device	The surface EMG is performed to assess the maximum voluntary contraction and muscle activity of upper limb muscles and accessory inspiratory muscles during performing simulated ADL tasks. The maximal voluntary contraction (MVC) is used as the reference level of muscle activity to normalize the EMG data of performing simulated ADL tasks. The muscle activity is reported in percentage.	baseline
Primary	The clinical Chronic Obstructive Pulmonary Disease questionnaire	This is a self-reported questionnaire to measure the impact of COPD on participants' health status. The rating scores is a 7-point scale (0=no limitation, 6=totally limited).Higher scores mean the more severe impact of COPD on participants' daily living.	baseline
Primary	Modified Borg Scale	This is a self-reported scale to measure how much participants perceive dyspnea. The range from 0 which means no difficulty to breathe to 10 which means with maximal difficulty to breathe.	baseline
Primary	Modified Medical Research Council	This is a five-point scale to assess the severity of breathlessness.	baseline
Secondary	EQ-5D questionnaire	This is a self-reported questionnaire for measuring generic health status	baseline