COPD Clinical Trial
Official title:
Effects of Heated Humidified High-Flow Nasal Cannula During Six-Minute Walk Test in Patient With COPD Undergoing Pulmonary Rehabilitation
The aim of this study is to investigate the use heated humidified high-flow nasal cannula (HHHFNC) in pulmonary rehabilitation and analysis of cardiopulmonary parameters in adult patients.
Objectives: The aim of this study is to investigate the use heated humidified high-flow nasal
cannula (HHHFNC) in pulmonary rehabilitation and analysis of cardiopulmonary parameters in
adult patients.
Background: Recently, HHHFNC has been used in both adult and neonates with post-extubation
respiratory support. Studies indicate that HHHFNC has similar efficacy compared to
non-invasive positive pressure ventilation and superior than conventional oxygen therapy.
Six-minute walking test (6-MWT) is a standardized laboratory tests to evaluate the endurance
capacity in adult patients. It helps clinician to modify the treatment plan. Cirio, et at.
has been shown HHHFNC may improve the exercise performance in severe chronic obstructive
pulmonary disease (COPD) patients with ventilatory limitation.
Study Design: This is a prospective clinical trial in a pulmonary rehabilitation out-patient
department (2018.08.01-2019.07.31).。 Methods: Patents with COPD who done pulmonary function
test will enroll to this study. Left-side heart failure, COPD acute-exacerbation (AE) within
3 months, diagnosed neuromuscular disease, and unable to perform 6-MWT will be exclude. The
data will be collected for and analyzed.
Effect: Investigators expect the exercise performance; cardiopulmonary function will be
improve under HHHFNC support. We hope the application of HHHFNC in adult patient with
pulmonary rehabilitation could enhance the quality of life.
Key words: chronic obstructive pulmonary disease; heated humidified high-flow nasal cannula;
pulmonary rehabilitation, six-minute walking test.
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