Autologous Transplantation of Bronchial Basal Cells for Treatment of COPD

Status Not yet recruiting

Clinical Trial Summary

Chronic Obstructive Pulmonary Disease (COPD) is a disease characterized by long-term poor airflow, resulting in chronic pulmonary heart disease, chronic respiratory failure or even death. Till now, the damaged pulmonary bronchus structures in COPD patients cannot be repaired by recent clinical methods so far. In this study, we intends to carry out a single-centered, non-randomized and self-controlled clinical trial at an early phase. During the process, autologous bronchial basal cells (BBCs) will be dissected from trial tissue from bronchoscopic brushing. Then the BBCs will be expanded and detected by quality control. In the following, qualified BBCs will be injected directly into the lesion by fiberoptic bronchoscopy after lavage. After six-month observation, the investigators will evaluate the safety and effectiveness of the treatment by measuring a serial of indicators, including occurrence of adverse events, pulmonary function, the CT imaging, 6 minute walk distance (6MWD), St. George's Respiratory Questionnaire (SGRQ), modified medical research council (mMRC) dyspnea scale and COPD assessment test (CAT).

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

COPD
Pulmonary Disease, Chronic Obstructive

Clinical Trial Details

NCT number	NCT03655795
Study type	Interventional
Source	Ruijin Hospital
Contact	Jieming Qu, M.D., Ph.D
Phone	+86-21-64370045
Email	jmqu0906@163.com
Status	Not yet recruiting
Phase	Phase 1
Start date	November 2018
Completion date	March 2021

View Details

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