COPD Clinical Trial
Official title:
The Association of Physical Activity Levels and Inflammatory Markers in COPD Patients Following Pulmonary Rehabilitation
COPD is characterised by irreversible airflow limitation that is usually progressive and
associated with an enhanced chronic inflammatory response. This inflammation can be amplified
with flare-ups that are commonly seen in COPD patients. Pulmonary rehabilitation is one of
the most effective methods of managing chronic obstructive pulmonary disease (COPD).
Pulmonary rehabilitation has been seen to induce improvements in functional capacity and
quality.
In healthy individuals, exercise has been shown to induce an anti-inflammatory response when
performed regularly. However, the effects of exercise on inflammation in COPD are unclear.
Our initial CIMPRES-COPD study has looked into the effects of short-term exercise, as part of
pulmonary rehabilitation, on inflammation. However, this trial will examine the inflammatory
response in COPD patients who are most active following pulmonary rehabilitation against
those who are least active.
This study will split participants into 2 groups according to physical activity level
following pulmonary rehabilitation. We will recruit 40 COPD patients who provided a sample in
the initial CIMPRES-COPD study to explore inflammatory responses in those who are most active
and least active. By better understanding the mechanisms of how long-term physical activity
levels affects inflammation in COPD, we could design better interventions to increase
physical activity levels following pulmonary rehabilitation.
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