Phenotypes of COPD

Chronic Obstructive Pulmonary Disease Clinical Trial

Official title:

Chronic Obstructive Pulmonary Disease Phenotypes in Non-Smokers

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT03432026
• Other study ID #: COPD
• Status: Not yet recruiting
• Start date: April 1, 2019
• Est. completion date: April 1, 2021

Study information

• Verified date: June 2018
• Source: Assiut University
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Chronic Obstructive Pulmonary Disease (COPD) has been defined by international guidelines as a common preventable and treatable disease characterized by persistent air flow limitation and respiratory symptoms caused by exposure to gases or noxious particles.

COPD is a major cause of morbidity and mortality worldwide. It is predicted to become the third leading cause of death and the fifth leading cause of disability by the year 2020.

Description:

Although the disease has been greatly associated with tobacco smoking, non- smokers can also have COPD, and the burden of COPD in non-smokers is also higher than previously believed especially in developing countries. Exposure to gases, environmental pollution, respiratory infection, noxious particles, passive smoking, and indoor air pollution is the main cause of COPD in non smokers.

COPD over the years has been classified into two phenotypes; chronic bronchitis or classic emphysema.However, The Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines over the last few years have stopped emphasizing the categorization of chronic obstructive pulmonary disease (COPD) into only emphysema or chronic bronchitis

Clear examples of COPD phenotypes in smokers have been described in different Researches,such as emphysema, chronic bronchitis, frequent exacerbators and the asthma_copd overlap.,but there is alack of information about COPD phenotypes in non-smokers, So, there is a continuous need for research into groups of non smoking patients.

Therefore, the aim of this study is to describe the phenotypes of COPD, their risk factors, Clinical and functional assessment and the prognosis of each COPD phenotype in non-smoking patients.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 50
• Est. completion date: April 1, 2021
• Est. primary completion date: April 1, 2020
• Gender: All
• Age group: N/A and older

Eligibility

Inclusion Criteria:

1. Non-smoker COPD patients.

2. Stable COPD patients (=4 weeks without exacerbation or worsening of any relevant comorbidity).

Exclusion Criteria:

1. Patients with COPD exacerbation.

2. Patients with associated obstructive sleep apnea.

3. Patients with associated interstitial lung disease.

4. patients with associated cardiac problems.

5. Patients with associated bronchiaectasis.

Related Conditions & MeSH terms

• Chronic Obstructive Pulmonary Disease
• Lung Diseases
• Lung Diseases, Obstructive
• Pulmonary Disease, Chronic Obstructive

Intervention

Device:
• High resolution computed tomography scan of the chest.
High resolution computed tomography scan of the chest & pulmonary function tests will be done for every patient to classify them.

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Assiut University

References & Publications (2)

Mohan A, Sharma M, Uniyal A, Borah R, Luthra K, Pandey RM, Madan K, Hadda V, Guleria R. Variability in proteinase-antiproteinase balance, nutritional status, and quality of life in stable chronic obstructive pulmonary disease due to tobacco and nontobacco etiology. Lung India. 2016 Nov-Dec;33(6):605-610. — View Citation

Sharma BB, Singh V. Nonsmoker COPD: Is it a reality? Lung India. 2017 Mar-Apr;34(2):117-119. doi: 10.4103/lungindia.lungindia_56_17. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Rate of risk factors of COPD in non smokers.	Complete medical history will be taken for each patient to detect risk factors of COPD.	48 hour