Chronic Obstructive Pulmonary Disease Clinical Trial
Official title:
Tolerance and Acute Effects of Humidified Nasal High-flow With Oxygen (HNHF-O2) on Gas Exchange in Patients Hospitalized With an Acute Exacerbation of COPD
Verified date | April 2018 |
Source | Temple University |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
The investigators are looking at the effect of humidified nasal high-flow with oxygen (HNHF-O2) on air exchange during exacerbations of COPD. HNHF-O2 therapy may have beneficial effects in patients with severe breathing impairment that results in low oxygen in the blood. Some studies show that patients with low blood oxygen levels who use HFNC oxygen have lower rates of needing mechanical ventilation.
Status | Completed |
Enrollment | 10 |
Est. completion date | April 18, 2018 |
Est. primary completion date | April 16, 2018 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 40 Years and older |
Eligibility |
Inclusion Criteria: - Males and females 40 years of age or older - Hospitalized for an acute exacerbation of COPD on the 6th floor of Rock Pavilion (pulmonary inpatient service) - Smoking history of > 10 pack-years - PaCO2 = 45 mm Hg - Able to provide informed consent - Willing to participate in daily measurements of arterial blood gases, completion of study questionnaires, and other study-related procedures Exclusion Criteria: - Upper airway or nasal problems that prohibit the use of humidified high-flow nasal oxygen - Hemodynamic instability defined as the need for blood pressure or blood volume support to maintain adequate tissue perfusion and oxygenation - Urgent need for endotracheal intubation - A do-not-intubate order - A known diagnosis of obstructive sleep apnea - Present use of continuous positive airway pressure (CPAP) or bilevel positive airway pressure (BIPAP) therapy |
Country | Name | City | State |
---|---|---|---|
United States | Temple University Hospital | Philadelphia | Pennsylvania |
Lead Sponsor | Collaborator |
---|---|
Temple University | Fisher and Paykel Healthcare |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Ability to maintain oxygen saturation at or above 90% | The need to intensify therapy because HNHF-O2 does not achieve the targeted oxygen saturation of = 90% resulting in the need to intensify respiratory support | 3 days | |
Secondary | Tolerance of HNHF-O2 measured by a 5-point Likert Scale | Likert scale model indicating marked improvement (+2), slight improvement (+1), no change (0), slight deterioration (-1) and marked deterioration (-2) in patient's sensation of shortness of breath. | 3 days | |
Secondary | Tolerance of HNHF-O2 measured by a 100 mm visual analog scale | Discomfort assessed using an unmarked 100 mm visual analogic scale from "no discomfort" to "maximal imaginable discomfort" | 3 days |
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