COPD Clinical Trial
Limitation of expiratory flows is considered as the main determiner of dynamic distension
and dyspnoea in chronic obstructive pulmonary disease (COPD). The analysis of proximal and
distal resistances should allow to better appreciate the functional impact.
This study should also allow to specify the best parameters in respiratory functional
explorations useful for the follow-up in COPD and to specify the relevance of functional
indications other than the forced expiration volume at 1 second (FEV1) or the functional
residual capacity (FRC) to estimate in a more relevant way the clinical improve with the
increase of the therapeutic load (increase of posology, association of two
bronchodilatators, addition of an anti-inflammatory drug, thus etc…) at already handled
patients suffering from a persistent dyspnoea insufficiently relieved.
n/a
Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic
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