COPD Clinical Trial
Official title:
A Crossover Clinical Pharmacology Study to Evaluate the Total Systemic Exposure and Lung Bioavailability of SUN-101 and Seebri® Breezhaler® Administered With and Without Activated Charcoal in Subjects With Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD)
The purpose of this research study is to determine the amount of medicine absorbed in the lungs following dosing via eFlow nebulizer and Seebri® Breezhaler® with and without activated charcoal in subjects with moderate to severe chronic obstructive pulmonary disease (COPD).
This is a randomized, open-label, single-dose per dosing period, five-way crossover study in
subjects 40 to 70 years of age with a diagnosis of moderate to severe COPD per Global
Initiative for Chronic Obstructive Lung Disease guidelines. After a subject provides consent
for study participation, there will be a Screening Period lasting up to 3 weeks to determine
study eligibility and to allow for appropriate washout of prohibited medications.
Eligible subjects will be randomized to one of 10 treatment Sequences. There will be a
minimum of a 7-day washout period between each treatment visit. At each visit, subjects will
receive one dose of study medication according to the sequence assigned.
Subjects with a ≥ 20% decrease in forced expiratory volume in one second (FEV1) based on
review of the Visit predose value compared with the Screening value will be evaluated by the
investigator for continuation in the study.
Subjects taking theophylline will not be able to participate in the study.
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