Effect of Pursed Lips Breathing on Chest Wall, Mobility Diaphragmatic and Exercise Tolerance in Patients With Chronic Obstructive Pulmonary Disease

Chronic Obstructive Pulmonary Disease Clinical Trial

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02424331
• Other study ID #: 19309213.3.0000.5208
• Status: Completed
• Phase: N/A
• First received: March 5, 2015
• Last updated: April 22, 2015
• Start date: March 2014
• Est. completion date: March 2015

Study information

• Verified date: April 2015
• Source: Universidade Federal de Pernambuco
• Contact: n/a
• Is FDA regulated: No
• Health authority: Brazil: Ethics Committee
• Study type: Interventional

Clinical Trial Summary

This study aimed to evaluate the acute effect of PLB technique on diaphragmatic mobility, the kinematics of the thoracoabdominal complex analysis of lung volumes and exercise tolerance in patients with Chronic Obstructive Pulmonary Disease (COPD). This is a study randomized cross-over clinical trial and blind, in subjects with Chronic Obstructive Pulmonary Disease (COPD) according to criteria of the Global Initiative for Chronic Obstructive Lung Disease (GOLD) (FEV1 / FVC <0.7 and FEV1 <80% predicted) selected at the Clinical Hospital of the Federal University of Pernambuco (UFPE) and Otavio de Freitas General Hospital (HGOF). The investigators recruited 13 patients COPD (according to previous sample calculation) aged between 40 and 80 years, of both sexes. The first day was held evaluation of lung function, respiratory muscle strength, body composition, dyspnea index and functional capacity. On the second day was held evaluation of thoracoabdominal complex kinematics by plethysmography Optoelectronics (OEP) with Quiet Breathing (QB) or pursed-lips breathing (PLB). Lung volumes with 2 minutes with QB and 6 minutes PLB or only 6 minutes by QB as randomization were observed. Before and after performing the requested breathing pattern diaphragmatic mobility was observed by Ultrasonography (US) and requested the patient an Inspiratory Capacity maneuver (IC). The evaluator who performed the ultrasound was blinded as to the beginning of the breathing pattern of order performed by the patient.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 14
• Est. completion date: March 2015
• Est. primary completion date: January 2015
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 40 Years to 80 Years

Eligibility

Inclusion Criteria:

• COPD diagnosis with stage II-IV (GOLD),

• Stable clinical condition (no exacerbation or hospital admission in the last four weeks preceding the study)

• Absence of other disease that may potentially contribute to dyspnea (heart disease, congestive heart failure, neuromuscular diseases, severe postural changes)

Exclusion Criteria:

• BMI> 30 kg / m2

• Musculoskeletal limitations

• Use of oxygen therapy

• Extreme discomfort during the procedure application

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Supportive Care

Related Conditions & MeSH terms

• Chronic Obstructive Pulmonary Disease
• Lung Diseases
• Lung Diseases, Obstructive
• Pulmonary Disease, Chronic Obstructive

Intervention

Other:
• Pursed Lips Breathing
Pursed Lips Breathing for six minutes.
• Quiet Breathing

Locations

Country	Name	City	State
Brazil	Clinical Hospital	Recife	Pernambuco

Sponsors (1)

Lead Sponsor	Collaborator
Universidade Federal de Pernambuco

Country where clinical trial is conducted

Brazil, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Chest wall (Analysis of lung volumes)	(L) by plethysmography optoelectronics.	One day during eight minutes	Yes
Primary	Mobility diaphragmatic (mobility diaphragmatic (mm) by Ultrassonography)	Analysis of mobility diaphragmatic (mm) by Ultrassonography.	One day, before and after eight minutes of pursed lips breathing	No
Primary	Exercise tolerance (Glittre AVD-Test)	Analysis by Glittre AVD-Test (capacity functional test) observing the test execution time (s).	One day, for six minutes approximately. The test will be repeated after 20 minutes of rest.	Yes
Secondary	Dyspnea (Borg and MRC Scale)	Assessed by Borg and MRC Scale (Medical Research Council).	One day, before and after implementation of Glittre-ADL Test	Yes