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Muscle Training Induced Angiogenesis in COPD — COPDµvasc  

COPD Clinical Trial

Official title:
Impact of Exercise Training on Skeletal Muscle Capillary Maturation During Angiogenesis in COPD Patients

Clinical Trial Summary

COPD patients experiment a peripheral muscle dysfunction which impact their exercise tolerance and health-related quality of life. The capillary to fiber interface is reduced and impact the exercise capacity of the patients. While the muscle capillary creation in response to exercise training is blunted in COPD patients, the maturation of the neo-capillaries could also be blunted and contribute to the impaired aniogionenesis in patients. Because the capillary maturation is a sensitive and dynamic process, only different modalities of exercise training and multiple time-points of measures would allow to capture this microvascular adaptation.

Aim of the study : Compare the muscle capillary maturation in response to training at 5 and 10 weeks, in sedentary healthy subject trained at the intensity of the ventilatory threshold (60-65% of VO2max), versus :- COPD patients trained at a similar intensity (60-65% of VO2max)- COPD patients trained at a similar absolute intensity (90% of VO2max).

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02040363
Study type Interventional
Source University Hospital, Montpellier
Contact
Status Completed
Phase N/A
Start date January 2014
Completion date August 2016
View Details
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