Chronic Obstructive Pulmonary Disease Clinical Trial
Official title:
Effect of Inspiratory Muscle Training in the Ventilatory Muscle Metaboreflex in Chronic Obstructive Pulmonary Disease Patients.
Verified date | December 2015 |
Source | Federal University of Rio Grande do Sul |
Contact | n/a |
Is FDA regulated | No |
Health authority | Brazil: Ethics Committee |
Study type | Interventional |
This research intends to evaluate if inspiratory muscle training (IMT) reduces inspiratory muscle metaboreflex through the decrease of calf vascular resistance and increase of calf blood flow in Chronic Obstructive Pulmonary Disease (COPD).
Status | Completed |
Enrollment | 13 |
Est. completion date | February 2015 |
Est. primary completion date | February 2015 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 18 Years to 85 Years |
Eligibility |
Inclusion Criteria: Selection of subjects will be made through the Hospital de Clinicas de Porto Alegre Pneumology Service's COPD ambulatory. The inclusion criteria consist of -patients with COPD with functional confirmation through spirometry as by previously defined criteria. Those selected must be classified as GOLD II-IV, with moderate to severe expiratory flow obstruction. Exclusion Criteria: Patients will be considered ineligible for this study if they - develop COPD exacerbation 8 weeks prior to recruitment - if systemic corticosteroids are utilized (in the last three months) - if there is history of acute myocardial infarction (in the last three months) - if there is presence of neuromuscular disease - history of cardiovascular disease or active smoking (in the last 6 months) - clinical history of peripheral vascular disease and if age is equal or superior to 85 years |
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Outcomes Assessor), Primary Purpose: Treatment
Country | Name | City | State |
---|---|---|---|
Brazil | Hospital de Clinicas de Porto Alegre | Porto Alegre | Rio Grande do Sul |
Lead Sponsor | Collaborator |
---|---|
Federal University of Rio Grande do Sul | Hospital de Clinicas de Porto Alegre |
Brazil,
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* Note: There are 34 references in all — Click here to view all references
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Calf blood flow | 8 weeks | No | |
Secondary | Time to exercise tolerance (tlim) | Exercise time during high intensity submaximal Cardiopulmonary exercise testing | 8 weeks | No |
Secondary | Maximum Inspiratory Pressure | 8 weeks | No | |
Secondary | The St George's Respiratory Questionnaire | 8 weeks | No | |
Secondary | Baseline Dyspnea Index/Transitional Dyspnea Index | 8 weeks | No | |
Secondary | Calf vascular resistance | Calf blood flow/mean arterial pressure | 8 weeks | No |
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