The Role of Resistance Exercise in Chronic Obstructive Pulmonary Disease Exacerbation

Chronic Obstructive Pulmonary Disease Clinical Trial

— RECOPD  

Official title:

Impact of Resistance Training During Hospitalization in COPD Patients: a Randomized and Controlled Trial

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01786928
• Other study ID #: PTR-001-RCB
• Status: Completed
• Phase: N/A
• First received: January 10, 2012
• Last updated: February 5, 2013
• Start date: April 2009
• Est. completion date: October 2010

Study information

• Verified date: February 2013
• Source: University of Sao Paulo
• Contact: n/a
• Is FDA regulated: No
• Health authority: Brazil: National Committee of Ethics in Research
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to determine whether resistance exercise are effective in combating the decline in muscle strength during an exacerbation of Chronic Obstructive Pulmonary Disease (COPD).

Description:

Acute exacerbations are common in patients with COPD and cause specific signs and symptoms, such as increased dyspnea, productive cough with altered sputum, and fever. With disease progression, exacerbations are frequent and have a negative impact on health related quality of life and pulmonary function as well as increase mortality. More severe exacerbations require hospitalization resulting in enormous health expenditures, severely reducing daily life activities and declining peripheral muscle strength that can be only partially reversed after 3 months. Despite many features have been pointed out as responsible for the decrease in muscle strength during hospitalization, physical inactivity seems the most important.

Resistance training is an interesting therapeutic option to prevent and/or reverse muscular dysfunction due to immobilised in healthy subjects and stable COPD patients because induces hypertrophy of type II fibers, increases muscle strength and exercise tolerance. In addition, provokes lower dyspnea perception during effort compared with other exercise training. Despite these benefits for stable COPD, the impact of a resistance exercise program during hospitalization remains poorly known.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 34
• Est. completion date: October 2010
• Est. primary completion date: December 2009
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 18 Years to 80 Years

Eligibility

Inclusion Criteria:

• patients hospitalized for exacerbation of COPD

Exclusion Criteria:

• patients presenting change in mental status (confusion, lethargy or coma)

• persistence or worsening in hypoxemia (PaO2<40mmHg) and/or respiratory acidosis (pH<7.25) despite oxygen supplementation or use of non-invasive ventilation

• hemodynamic instability requiring vasoactive drugs

• patients transferred to ICU

• hospitalization lower than 5 days

• diseases that prevented the exercises

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

• Chronic Obstructive Pulmonary Disease
• Lung Diseases
• Lung Diseases, Obstructive
• Pulmonary Disease, Chronic Obstructive

Intervention

Other:
• Resistance training
Resistance training group received training program for upper (shoulder flexion and abduction and biceps) and lower limbs (knee extension and flexion and hip flexion). Daily exercise for every muscle was performed with free weights at 80% of an maximal repetition test and a 4 minutes rest was allowed between each step.

Locations

Country	Name	City	State
Brazil	University Hospital of sao paulo	São Paulo

Sponsors (2)

Lead Sponsor	Collaborator
University of Sao Paulo	Fundação de Amparo à Pesquisa do Estado de São Paulo

Country where clinical trial is conducted

Brazil, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	The benefits of resistance training during exacerbation of COPD on peripheral muscle strength during hospitalization	The metric used to evaluate the strength gain is given in kilogram (absolute value) and percentage relative to that obtained on the second hospital day	Will be evaluated on the second day of hospitalization, the day of hospital discharge (this time interval must be longer than five days)	Yes
Secondary	The benefits of resistance training during exacerbation of COPD on physical activity in daily life	The metric used to evaluate the changes will be given in minutes and percentage of total time	Will be evaluated in the third and fifth day of hospitalization and thirty days after discharge	Yes