Chronic Obstructive Pulmonary Disease Clinical Trial
Official title:
Comparative Effects of Noninvasive Proportional Assist and Pressure Support Ventilation on Neural Respiratory Drive in Recovering Acute Exacerbation of Chronic Obstructive Pulmonary Disease(AECOPD) Patients
Background: The efficiency of Neural respiratory drive (NRD)expressed by a ratio of
ventilation to the diaphragm electromyogram (EMGdi) decreases in patients with COPD
.Improving the neural respiratory drive efficiency of COPD will help to relieve the clinical
symptom and make the patients feel comfort.Noninvasive positive pressure ventilation(NPPV)is
a good treatment to AECOPD patients.It is unknown the effects of different mode of
noninvasive positive pressure ventilation(NPPV) such as proportional assist ventilation
(PAV) and pressure-support ventilation (PSV) on the efficiency of Neural drive of AECOPD and
which mode benefit the patients more.
Objective: To compare the short-term effects of mask pressure support ventilation (PSV) and
proportional assist ventilation (PAV) on Neural respiratory drive in recovering patients of
AECOPD
Status | Completed |
Enrollment | 20 |
Est. completion date | April 2013 |
Est. primary completion date | April 2013 |
Accepts healthy volunteers | No |
Gender | Male |
Age group | 50 Years to 75 Years |
Eligibility |
Inclusion Criteria: - Clinical diagnosis of the COPD (Chronic Obstructive Pulmonary Disease) the COPD patients were all in stable condition during recovery from acute exacerbation. Exclusion Criteria: - severe Cardiovascular disease - Pneumonia - neuromuscular and chest wall deformity - Respiratory arrest - Cardiovascular instability (hypotension, arrhythmias, myocardial infarction) - Change in mental status; uncooperative patient - High aspiration risk - Viscous or copious secretions - Recent facial or gastroesophageal surgery - Craniofacial trauma - Fixed nasopharyngeal abnormalities - Burns - Extreme obesity |
Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Single Blind (Subject), Primary Purpose: Treatment
Country | Name | City | State |
---|---|---|---|
China | TheFirst Affiliated Hospital Of Guangzhou Medical Collage | Guangzhou | Guangdong |
Lead Sponsor | Collaborator |
---|---|
The First Affiliated Hospital of Guangzhou Medical University |
China,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | change of the Neural respiratory drive | In recent studies, The efficiency of neural respiratory drive(NRD) as expressed as a ratio of minute ventilation to diaphragm electromyogram (EMGdi) in patients with COPD is lower than that in healthy subject, suggesting that, to achieve the same minute ventilatory volume, a higher neural drive is required for patients with COPD than for healthy individuals.Furthermore,levels of neural respiratory drive were related to disease severity and dyspnea.Improving the neural respiratory drive efficiency of COPD will help to relieve the clinical symptom and make the patients feel comfort. Because dyspnea relates to respiratory effort.Neural respiratory drive(NRD) and its efficiency as expressed by a ratio of ventilation to the diaphragm electromyogram(EMGdi)may be a good tool to evaluate treatment benefits in Patients with COPD.This study want to investigate the effect of noninvasive positive pressure ventilation(NPPV)on the Neural respiratory drive of COPD patients | 15-20 minute | Yes |
Secondary | change of the pressure-time product(PTP) | The pressure-time product(PTP)means inspiratory effort of the inspiratory muscle In COPD lung mechanical abnormality including airflow obstruction and dynamic hyperinflation and intrinsic positive end-expiratory pressure increase the work load of the respiratory muscles,which will lead to higher inspiratory work. As a result,The efficiency of neural respiratory drive as expressed as a ratio of minute ventilation to diaphragm electromyogram (EMGdi) in patients with COPD is lower than that in healthy subject.This study want to investigate the effect of noninvasive positive pressure ventilation(NPPV)on the inspiratory muscle load of the COPD patients | 15-20 minute | Yes |
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