COPD Clinical Trial
Official title:
ECOS: A Study of Chronic Obstructive Pulmonary Disease (COPD) Exacerbations In Spain (o Estudio de Las Exacerbaciones de la EPOC en España)
ECOS is a cross-sectional, observational, longitudinal, multicenter study enrolling 100-200 patients during a COPD exacerbation.
Patients will be followed for 12 months. Information to be collected includes clinical,
analytical, immunological, microbiological, hemodynamic, imaging, environmental, social and
other blood markers of inflammation (IL-8, IL-6, TNF, TNF-alpha, endothelin-1, SLPI, IL10,
TGF-beta and markers oxidative stress (TEAC)), and sputum (cell count, IL-6, IL-8, SLPI, ET
1, IL10).
Each center will collect clinical data, blood gas, microbiological and functional data for
their patients, which will be centralized through the website of the Red Respira
(www.redrespira.net).
A frozen serum sample and another of frozen sputum supernatant will be sent to the
coordinating center (Palma de Mallorca).
Statistical analysis will include descriptive statistics: mean, standard deviation and
range. Comparison of quantitative variables to be assessed using Student's t-test and ANOVA.
Correlations between variables will be performed using bivariate analyzes (Pearson's linear
correlation coefficient) and multivariate (multiple regression) analyses, among others.
;
Observational Model: Case-Crossover, Time Perspective: Prospective
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